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Protein Ontology Report - hAKT1

PR:P31749 - http://purl.obolibrary.org/obo/PR_P31749
This page represents a class of proteins encompassing all the protein products of the AKT1 gene in human.
Ontology Information
PRO ID PR:P31749 Show OBO stanza / PAF
PRO name RAC-alpha serine/threonine-protein kinase (human)
Synonyms
PRO-short-label: hAKT1
EXACT: PKB alpha (human); RAC-PK-alpha (human); protein kinase B (human); protein kinase B alpha (human); proto-oncogene c-Akt (human)
Gene-based: AKT1; PKB; RAC
Definition A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31749]
PRO Category organism-gene
Parent PR:000002190 RAC-alpha serine/threonine-protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 6
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000002190
AKT1
has_part Pfam:PF00433 Protein kinase C terminal domain
has_part Pfam:PF00069 Protein kinase domain
has_part Pfam:PF00787 PX domain
has_part Pfam:PF00169 PH domain
PR:000028994
hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
capable_of GO:0004674 protein serine/threonine kinase activity PMID:12138205
capable_of GO:0004672 protein kinase activity PMID:8978681
capable_of GO:0005515 protein binding with PR:O14746-1 hTERT/iso:1 PMID:12586360
capable_of GO:0005515 protein binding with PR:P41279-1 hMAP3K8/iso:1 PMID:12138205
participates_in GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
participates_in GO:0032869 cellular response to insulin stimulus PMID:8978681
PR:000027473
hAKT1/iso:1/Phos:2
Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
participates_in GO:0043066 negative regulation of apoptotic process PMID:16549426
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000027473 hAKT1/iso:1/Phos:2
Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
PMID:16549426
GO:0051092 positive regulation of NF-kappaB transcription factor activity PR:000028994 hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
PMID:12138205
GO:0032869 cellular response to insulin stimulus PR:000028994 hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
PMID:8978681

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