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Protein Ontology Report - hTTK

PR:P33981 - http://purl.obolibrary.org/obo/PR_P33981
This page represents a class of proteins encompassing all the protein products of the TTK gene in human.
Ontology Information
PRO ID PR:P33981 Show OBO stanza / PAF
PRO name dual specificity protein kinase TTK (human)
Synonyms
PRO-short-label: hTTK
EXACT: PYT (human); phosphotyrosine picked threonine-protein kinase (human)
Gene-based: MPS1; MPS1L1; TTK
Definition A dual specificity protein kinase TTK that is encoded in the genome of human. [PMID:20823832, PRO:KER]
PRO Category organism-gene
Parent PR:000016787 dual specificity protein kinase TTK
Gene Template HGNC:12401 TTK
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P33981
hTTK
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-590746
located_in GO:0000776 kinetochore PMID:20624902
participates_in GO:0032092 positive regulation of protein binding PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
participates_in GO:0034501 protein localization to kinetochore PMID:22732840
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0032092 positive regulation of protein binding PMID:22660415
participates_in GO:0031577 spindle checkpoint PMID:20624902
participates_in GO:0051310 metaphase plate congression PMID:20624902, PMID:22732840
participates_in GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
PR:000045754
hTTK/Phos:1
Thr-676, MOD:00047
capable_of GO:0004672 protein kinase activity PMID:18680479
participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
participates_in GO:0051298 centrosome duplication PMID:17728254
participates_in GO:0071174 mitotic spindle checkpoint PMID:18083840
PR:000049845
hTTK/p(Act-loop_P+1-loop)
capable_of GO:0004672 protein kinase activity PMID:19120698
PR:000049844
hTTK/pActloop
capable_of GO:0004672 protein kinase activity PMID:18680479, PMID:19120698
participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0045841 negative regulation of mitotic metaphase/anaphase transition PR:P33981 hTTK

PMID:20624902
GO:0034501 protein localization to kinetochore PR:P33981 hTTK

PMID:20624902, PMID:22732840
PR:P33981 hTTK

PMID:20624902, PMID:22732840
PR:P33981 hTTK

PMID:22732840
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
GO:0071174 mitotic spindle checkpoint PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:18083840
NOT GO:0034501 protein localization to kinetochore PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
GO:0032092 positive regulation of protein binding PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:22660415
GO:0046777 protein autophosphorylation PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:18680479, PMID:19120698
PR:000049844 hTTK/pActloop

PMID:18680479, PMID:19120698
GO:0051298 centrosome duplication PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:17728254
GO:0031577 spindle checkpoint PR:P33981 hTTK

PMID:20624902
GO:0051310 metaphase plate congression PR:P33981 hTTK

PMID:20624902, PMID:22732840
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P33981 hTTK

PMID:20624902

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