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Protein Ontology Report - hTGFBR1

PR:P36897 - http://purl.obolibrary.org/obo/PR_P36897
This page represents a class of proteins encompassing all the protein products of the TGFBR1 gene in human.
Ontology Information
PRO ID PR:P36897 Show OBO stanza / PAF
PRO name TGF-beta receptor type-1 (human)
Synonyms
PRO-short-label: hTGFBR1
EXACT: ALK-5 (human); TGF-beta receptor type I (human); TGF-beta type I receptor (human); TGFR-1 (human); TbetaR-I (human); activin A receptor type II-like protein kinase of 53kD (human); activin receptor-like kinase 5 (human); serine/threonine-protein kinase receptor R4 (human); transforming growth factor-beta receptor type I (human)
Gene-based: ALK5; SKR4; TGFBR1
Definition A TGF-beta receptor type-1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P36897]
PRO Category organism-gene
Parent PR:000000047 TGF-beta receptor type-1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 14
organism-modification 4
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTGFBR1 forms found in complexes
hTGFBR1 Component Complexes
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000189
hTGFBR1/var:K232E
Lys-232, CHEBI:29972
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:16928994
PR:000000191
hTGFBR1/var:N267H
Asn-267, CHEBI:29979
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:16791849
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
capable_of GO:0005025 transforming growth factor beta receptor activity, type I PMID:7774578, PMID:8947046
located_in GO:0005887 integral component of plasma membrane PMID:8947046
participates_in GO:0006468 protein phosphorylation PMID:7774578
participates_in GO:0007165 signal transduction PMID:8242743
participates_in GO:0007181 transforming growth factor beta receptor complex assembly PMID:8947046
PR:P36897-1
hTGFBR1/iso:1
participates_in GO:0007165 signal transduction PMID:8242743
PR:000000188
hTGFBR1/var:11
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9661882
participates_in GO:0007165 signal transduction PMID:9661882
PR:000036432
hTGFBR1/iso:1/SigPep-
located_in GO:0005887 integral component of plasma membrane PMID:8242743
participates_in GO:0007165 signal transduction PMID:8242743
participates_in GO:0007181 transforming growth factor beta receptor complex assembly PMID:8242743
PR:000000190
hTGFBR1/var:S241L
Ser-241, CHEBI:30006
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:16596670, PMID:16791849
PR:000000196
hTGFBR1/var:R487W
Arg-487, CHEBI:29954
associated_with_disease_progression DOID:14756 autosomal dominant type IV Ehlers-Danlos syndrome PMID:16928994
PR:000000194
hTGFBR1/var:R487P
Arg-487, CHEBI:50342
associated_with_disease_progression DOID:14756 autosomal dominant type IV Ehlers-Danlos syndrome PMID:15731757, PMID:16928994
PR:000000195
hTGFBR1/var:R487E
Arg-487, CHEBI:29972
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:16791849, PMID:16928994
PR:000000192
hTGFBR1/var:M318R
Met-318, CHEBI:29952
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000193
hTGFBR1/var:D400G
Asp-400, CHEBI:29947
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
PR:000000187
hTGFBR1/var:10
has_agent SO:0001605 amino_acid_insertion PMID:9661882
PR:000000186
hTGFBR1/var:T200I
Thr-200, CHEBI:30009
associated_with_disease_progression DOID:0050466 Loeys-Dietz syndrome PMID:15731757
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007181 transforming growth factor beta receptor complex assembly PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep-

PMID:8242743
GO:0006468 protein phosphorylation PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:7774578
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000188 hTGFBR1/var:11

PMID:9661882
GO:0007165 signal transduction PR:000000188 hTGFBR1/var:11

PMID:9661882
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8242743
PR:000036432 hTGFBR1/iso:1/SigPep-

PMID:8242743
PR:P36897-1 hTGFBR1/iso:1

PMID:8242743
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005887 integral component of plasma membrane PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep-

PMID:8242743

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