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Protein Ontology Report - hSMAD3

PR:P84022 - http://purl.obolibrary.org/obo/PR_P84022
This page represents a class of proteins encompassing all the protein products of the SMAD3 gene in human .
Ontology Information
PRO ID PR:P84022 Show OBO stanza / PAF
PRO name mothers against decapentaplegic homolog 3 (human)
Synonyms
PRO-short-label: hSMAD3
EXACT: JV15-2 (human); MAD homolog 3 (human); Mad3 (human); SMAD 3 (human); SMAD family member 3 (human); Smad3 (human); hMAD-3; mothers against DPP homolog 3 (human)
RELATED: MADH3
Definition A smad3 that is encoded in the genome of human.
PRO Category organism-gene
Parent PR:000000365 smad3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 4
organism-modification 5
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036557
hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00723|Ser-423/Ser-425, MOD:00046
capable_of GO:0003700 DNA-binding transcription factor activity PMID:17074756
located_in GO:0005634 nucleus PMID:17074756
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
PR:P84022-1
hSMAD3/iso:1
capable_of GO:0005515 protein binding with PR:O95405-1 hZFYVE9/iso:1 PMID:12154125
capable_of GO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
located_in GO:0005737 cytoplasm PMID:17074053
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
PR:000026333
hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
capable_of GO:0008134 transcription factor binding PMID:15084259
capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:15350224, PMID:9311995
capable_of GO:0003700 DNA-binding transcription factor activity PMID:10823886, PMID:12943993
located_in GO:0005634 nucleus PMID:10846168, PMID:15280432
part_of GO:0005667 transcription factor complex PMID:12374795
participates_in GO:0006366 transcription by RNA polymerase II PMID:10823886
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881, PMID:9380693
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006366 transcription by RNA polymerase II PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:8774881, PMID:9380693
PR:000036557 hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00723|Ser-423/Ser-425, MOD:00046
PMID:17074756
PR:P84022-1 hSMAD3/iso:1

PMID:8774881
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:10846168, PMID:15280432
PR:000036557 hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00723|Ser-423/Ser-425, MOD:00046
PMID:17074756
GO:0005737 cytoplasm PR:P84022-1 hSMAD3/iso:1

PMID:17074053

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