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Protein Ontology Report - hBTK

PR:Q06187 - http://purl.obolibrary.org/obo/PR_Q06187
This page represents a class of proteins encompassing all the protein products of the BTK gene in human .
Ontology Information
PRO ID PR:Q06187 Show OBO stanza / PAF
PRO name tyrosine-protein kinase BTK (human)
Synonyms
PRO-short-label: hBTK
EXACT: B-cell progenitor kinase (human); agammaglobulinemia tyrosine kinase (human); bruton tyrosine kinase (human)
RELATED: AGMX1; ATK; BPK
Definition A tyrosine-protein kinase BTK that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q06187]
PRO Category organism-gene
Parent PR:000002110 tyrosine-protein kinase BTK
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 4
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBTK forms found in complexes
hBTK Component Complexes
PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000044351 hBTK/InitMet- PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000044351 hBTK/InitMet- PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
PR:000002110
BTK
has_part Pfam:PF07714 Protein tyrosine kinase
has_part Pfam:PF00017 SH2 domain
has_part Pfam:PF00018 SH3 domain
has_part Pfam:PF00779 BTK motif
has_part Pfam:PF00169 PH domain
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282

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