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Protein Ontology Report - hRIPK1

PR:Q13546 - http://purl.obolibrary.org/obo/PR_Q13546
This page represents a class of proteins encompassing all the protein products of the RIPK1 gene in human.
Ontology Information
PRO ID PR:Q13546 Show OBO stanza / PAF
PRO name receptor-interacting serine/threonine-protein kinase 1 (human)
Synonyms
PRO-short-label: hRIPK1
EXACT: RIP-1 (human); cell death protein RIP (human); receptor-interacting protein 1 (human)
Gene-based: RIP; RIP1; RIPK1
Definition A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx]
PRO Category organism-gene
Parent PR:000014022 receptor-interacting serine/threonine-protein kinase 1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hRIPK1 forms found in complexes
hRIPK1 Component Complexes
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000036051 hRIPK1/K63polyUbiq:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13546 hRIPK1 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
PR:Q13546 hRIPK1 PR:000028434 TRAF2:TRADD:RIP1 complex (human)
PR:Q13546 hRIPK1 PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:Q13546 hRIPK1 PR:000028437 TRAF2:TRADD:RIP1:FADD (human)
PR:Q13546 hRIPK1 PR:000028435 TRADD:TRAF2:RIP1:FADD:caspase-8 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036051
hRIPK1/K63polyUbiq:1
Lys-377, PR:000044772
located_in GO:0005737 cytoplasm Reactome:REACT_26236
PR:000036049
K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25755
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036058
rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036024
rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036649
hRIPK1/iso:1/Ubiq:1
capable_of GO:0005515 protein binding with PR:Q8C669 mPELI1 PMID:19734906
PR:000037334
rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037336
rip1:rip3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037362
K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000036051 hRIPK1/K63polyUbiq:1
Lys-377, PR:000044772
Reactome:REACT_26236
GO:0010008 endosome membrane PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25755
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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