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Protein Ontology Report - hIKBKE

PR:Q14164 - http://purl.obolibrary.org/obo/PR_Q14164
This page represents a class of proteins encompassing all the protein products of the IKBKE gene in human .
Ontology Information
PRO ID PR:Q14164 Show OBO stanza / PAF
PRO name inhibitor of nuclear factor kappa-B kinase subunit epsilon (human)
Alternate ID PR:000028685
Synonyms
PRO-short-label: hIKBKE
EXACT: I-kappa-B kinase epsilon (human); IKK-E (human); IKK-epsilon (human); IKK-i (human); IkBKE (human); inducible I kappa-B kinase (human)
RELATED: IKKE; IKKE (human); IKKI; IKKI (human); KIAA0151
Definition An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of human. [PMID:10882136, PMID:17327220, PRO:CNA, UniProtKB:Q14164]
PRO Category organism-gene
Parent PR:000001778 inhibitor of nuclear factor kappa-B kinase subunit epsilon
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIKBKE forms found in complexes
hIKBKE Component Complexes
PR:000028691 hIKBKE/Phos:1 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028691 hIKBKE/Phos:1 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028691 hIKBKE/Phos:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028691 hIKBKE/Phos:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000028691 hIKBKE/Phos:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028691 hIKBKE/Phos:1 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036124
p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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