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Protein Ontology Report - hTICAM2

PR:Q86XR7 - http://purl.obolibrary.org/obo/PR_Q86XR7
This page represents a class of proteins encompassing all the protein products of the TICAM2 gene in human.
Ontology Information
PRO ID PR:Q86XR7 Show OBO stanza / PAF
PRO name TIR domain-containing adapter molecule 2 (human)
Synonyms
PRO-short-label: hTICAM2
EXACT: MyD88-4 (human); TICAM-2 (human); TRIF-related adapter molecule (human); Toll-like receptor adaptor protein 3 (human); Toll/interleukin-1 receptor domain-containing protein (human); putative NF-kappa-B-activating protein 502 (human)
Gene-based: TICAM2; TIRAP3; TIRP; TRAM
Definition A TIR domain-containing adapter molecule 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q86XR7]
PRO Category organism-gene
Parent PR:000001750 TIR domain-containing adapter molecule 2
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 2
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTICAM2 forms found in complexes
hTICAM2 Component Complexes
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000028678 ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036056
rip3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_152149
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035715
pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25867
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000028678
ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_7083
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036041
K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_124855
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000027208
ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_7861
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036049
K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25755
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000028680
traf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036058
rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26039
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036027
sarm:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_151758
participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758
PR:000036123
p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036024
rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
PR:000036124
p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028678 ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
GO:0034142 toll-like receptor 4 signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028678 ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151758
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_7861
PR:000028678 ticam2:activated TLR4 complex (human)

Reactome:REACT_7083
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25867
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151758
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124855
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25755
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_152149
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959

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