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Protein Ontology Report - mSMAD3

PR:Q8BUN5 - http://purl.obolibrary.org/obo/PR_Q8BUN5
This page represents a class of proteins encompassing all the protein products of the SMAD3 gene in mouse.
Ontology Information
PRO ID PR:Q8BUN5 Show OBO stanza / PAF
PRO name mothers against decapentaplegic homolog 3 (mouse)
Synonyms
PRO-short-label: mSMAD3
EXACT: MAD homolog 3 (mouse); SMAD 3 (mouse); SMAD family member 3 (mouse); mMad3; mothers against DPP homolog 3 (mouse)
Gene-based: Madh3; Smad3
RELATED: Mad3 (mouse); Smad3 (mouse)
Definition A smad3 that is encoded in the genome of mouse. [OMA:Q8BUN5, PRO:DNx]
PRO Category organism-gene
Parent PR:000000365 smad3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036560
mSMAD3/iso:1/Phos:2
Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
capable_of GO:0003700 DNA-binding transcription factor activity decreased relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561
mSMAD3/iso:1/Phos:3
Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
capable_of NOT GO:0003713 transcription coactivator activity PMID:10197981
located_in GO:0005737 cytoplasm PMID:10197981
PR:Q8BUN5-1
mSMAD3/iso:1
capable_of GO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
capable_of GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
PR:000036558
mSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
capable_of GO:0003700 DNA-binding transcription factor activity PMID:10823886, PMID:12943993
capable_of GO:0008134 transcription factor binding PMID:15464984, PMID:9702197
capable_of GO:0003690 double-stranded DNA binding PMID:15282343
located_in GO:0005634 nucleus PMID:12943993, PMID:15282343
part_of GO:0005667 transcription factor complex PMID:9702197
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:Q8BUN5-1 mSMAD3/iso:1

PMID:12543979
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036558 mSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:12943993, PMID:15282343
GO:0005737 cytoplasm PR:000036561 mSMAD3/iso:1/Phos:3
Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
PMID:10197981

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