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Protein Ontology Report - hTICAM1

PR:Q8IUC6 - http://purl.obolibrary.org/obo/PR_Q8IUC6
This page represents a class of proteins encompassing all the protein products of the TICAM1 gene in human .
Ontology Information
PRO ID PR:Q8IUC6 Show OBO stanza / PAF
PRO name TIR domain-containing adapter molecule 1 (human)
Alternate ID PR:000028675
Synonyms
PRO-short-label: hTICAM1
EXACT: MyD88-3 (human); NF-kappa-B-activating protein 502H (human); TICAM-1 (human); TIR domain-containing adapter protein inducing IFN-beta (human); Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta (human); proline-rich, vinculin and TIR domain-containing protein B (human)
RELATED: PRVTIRB; TRIF
Definition A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000001749 TIR domain-containing adapter molecule 1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 0
organism-modification 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTICAM1 forms found in complexes
hTICAM1 Component Complexes
PR:Q8IUC6 hTICAM1 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8IUC6 hTICAM1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8IUC6 hTICAM1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000035715
pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25867
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036041
K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_124855
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000027208
ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_7861
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036049
K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25755
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036027
sarm:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_151758
participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758
PR:000036123
p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036024
rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
PR:000037307
ticam1:viral dsRNA:TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037322
p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000028680
traf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037340
pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037362
K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036124
p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037344
traf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036056
rip3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_152149
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036058
rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_151344
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26039
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037315
K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037310
traf3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037330
SARM:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037332
rip3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037334
rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037336
rip1:rip3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034142 toll-like receptor 4 signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
GO:0034138 toll-like receptor 3 signaling pathway PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151758
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_7861
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25867
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151758
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124855
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25755
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_152149
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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