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Protein Ontology Report - inhibitory smad protein

PR:000000099 -
Ontology Information
PRO ID PR:000000099 Show OBO stanza / PAF
PRO name inhibitory smad protein
Definition A smad protein that is an antagonist of the transforming growth factor beta (TGF-beta) superfamily signaling pathways. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads. [PMID:11532220]
PRO Category family
Parent PR:000000027 smad protein
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
inhibitory smad protein
acts_upstream_of_or_within GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PIRSF:PIRSF500412
acts_upstream_of_or_within GO:0030514 negative regulation of BMP signaling pathway PIRSF:PIRSF500412
acts_upstream_of_or_within GO:0009968 negative regulation of signal transduction PIRSF:PIRSF500412