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Protein Ontology Report - NODAL

PR:000000105 - http://purl.obolibrary.org/obo/PR_000000105
Ontology Information
PRO ID PR:000000105 Show OBO stanza / PAF
PRO name nodal protein
Synonyms
PRO-short-label: EXACT: NODAL
Definition A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation. [PRO:CNA]
PRO Category gene
Parent PR:000000008 TGF-beta-like cystine-knot cytokine
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 3
modification 2 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P43021-1
mNODAL/iso:1
capable_of GO:0042803 protein homodimerization activity PMID:15649361
located_in GO:0005615 extracellular space PMID:15649361
participates_in GO:0007368 determination of left/right symmetry PMID:12654299
participates_in GO:0009952 anterior/posterior pattern specification PMID:15004567
PR:000000105
NODAL
capable_of GO:0016015 morphogen activity PIRSF:PIRSF037400
participates_in GO:0007368 determination of left/right symmetry PIRSF:PIRSF037400
PR:000036469
mNODAL/iso:1/SigPep-
capable_of GO:0042803 protein homodimerization activity PMID:15649361
located_in GO:0005615 extracellular space PMID:15649361
participates_in GO:0007368 determination of left/right symmetry PMID:12654299
participates_in GO:0009952 anterior/posterior pattern specification PMID:15004567
PR:000000292
hNODAL/var:R183Q
Arg-183, CHEBI:30011
associated_with_disease_progression DOID:0050545 visceral heterotaxy PMID:9354794
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007368 determination of left/right symmetry PR:000000105 NODAL

PIRSF:PIRSF037400
PR:000036469 mNODAL/iso:1/SigPep-

PMID:12654299
PR:P43021-1 mNODAL/iso:1

PMID:12654299
GO:0009952 anterior/posterior pattern specification PR:000036469 mNODAL/iso:1/SigPep-

PMID:15004567
PR:P43021-1 mNODAL/iso:1

PMID:15004567
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036469 mNODAL/iso:1/SigPep-

PMID:15649361
PR:P43021-1 mNODAL/iso:1

PMID:15649361

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