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Protein Ontology Report - ROCK1

PR:000000120 - http://purl.obolibrary.org/obo/PR_000000120
Ontology Information
PRO ID PR:000000120 Show OBO stanza / PAF
PRO name Rho-associated protein kinase 1
Synonyms
PRO-short-label: EXACT: ROCK1
Other: EXACT: ROCK-I | Rho-associated, coiled-coil-containing protein kinase I | p160 ROCK-1 | p160ROCK | renal carcinoma antigen NY-REN-35 | rho-associated, coiled-coil-containing protein kinase 1
Definition A Rho-associated protein kinase that is a translation product of the human ROCK1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000024 Rho-associated protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 5
modification 5 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036476
mROCK1/iso:1/Clv:1
acts_upstream_of_or_within GO:0030036 actin cytoskeleton organization PMID:11283607, PMID:16983089
acts_upstream_of_or_within GO:0010659 cardiac muscle cell apoptotic process PMID:16983089
PR:000044586
hROCK1/iso:1/UnMod
enables GO:0004674 protein serine/threonine kinase activity PMID:15699075
enables GO:0004674 protein serine/threonine kinase activity PMID:11283607
PR:Q13464-1
hROCK1/iso:1
acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:10436159
acts_upstream_of_or_within GO:0007266 Rho protein signal transduction PMID:8798490
acts_upstream_of_or_within GO:0051260 protein homooligomerization PMID:15291762
acts_upstream_of_or_within GO:0030036 actin cytoskeleton organization PMID:10436159
enables GO:0031267 small GTPase binding PMID:14660612, PMID:15475352
enables GO:0004674 protein serine/threonine kinase activity PMID:8798490
PR:000026340
hROCK1/iso:1/Clv:1
acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:11283607
enables GO:0004674 protein serine/threonine kinase activity increased relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607

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