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Protein Ontology Report - fam:RHO

PR:000000122 -
Ontology Information
PRO ID PR:000000122 Show OBO stanza / PAF
PRO name Rho-related small GTPase
PRO-short-label: EXACT: fam:RHO
Definition A small GTPase with a short insert (approximately 13 residues) coincident with loop 8 of Ras. This insert region forms a highly charged helix without dramatic disturbance of the global structure shared with other small GTPases. Rho-related small GTPases act as key transducers of extracellular signals to regulate the actin cytoskeleton, cell cycle progression and gene expression. [PMID:11463812]
PRO Category family
Parent PR:000000028 small GTPase
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
acts_upstream_of_or_within GO:0007264 small GTPase mediated signal transduction PIRSF:PIRSF037169
acts_upstream_of_or_within GO:0007266 Rho protein signal transduction PIRSF:PIRSF037169
acts_upstream_of_or_within GO:0000902 cell morphogenesis PIRSF:PIRSF037169
enables GO:0005525 GTP binding PIRSF:PIRSF037169
enables GO:0005515 protein binding PIRSF:PIRSF037169
enables GO:0003924 GTPase activity PIRSF:PIRSF037169