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Protein Ontology Report - SP1

PR:000000133 - http://purl.obolibrary.org/obo/PR_000000133
Ontology Information
PRO ID PR:000000133 Show OBO stanza / PAF
PRO name transcription factor Sp1
Synonyms
PRO-short-label: EXACT: SP1
Gene-based: RELATED: TSFP1
Definition A transcription factor Sp that is a translation product of the human SP1 gene or a 1:1 ortholog thereof. It comprises the exons that code for an N-terminal inhibitory domain, two serine/threonine stretches adjacent to activation domains and three zinc fingers. [PRO:CNA]
PRO Category gene
Parent PR:000000032 transcription factor Sp
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 5
modification 14 organism-modification 11
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036496
hSP1/iso:1/Ac:1
acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:15647279
enables GO:0003677 DNA binding PMID:15647279
located_in GO:0005634 nucleus PMID:15647279
PR:000036497
hSP1/iso:1/Clv:1
enables GO:0003700 DNA-binding transcription factor activity PMID:16407261
located_in GO:0005634 nucleus PMID:16407261
PR:000036500
hSP1/iso:1/Phos:2
Thr-579, MOD:00047 		enables GO:0003700 DNA-binding transcription factor activity decreased relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:9153193
located_in GO:0005634 nucleus PMID:9153193
PR:000036501
hSP1/iso:1/Phos:3
Ser-59, MOD:00046 		enables GO:0003700 DNA-binding transcription factor activity increased relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:17049555, PMID:18239466
located_in GO:0005634 nucleus PMID:17049555, PMID:18239466
PR:000036502
hSP1/iso:1/Phos:4
acts_upstream_of_or_within GO:0042770 signal transduction in response to DNA damage PMID:18171990
located_in GO:0005634 nucleus PMID:18171990
PR:000036503
hSP1/iso:1/Sumo:1
Lys-16, MOD:01149 		enables GO:0003700 DNA-binding transcription factor activity decreased relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:16407261
PR:P08047-1
hSP1/iso:1
located_in GO:0005634 nucleus PMID:2170018
PR:000036498
hSP1/iso:1/OGlyco:1
Ser-491, MOD:00805 		enables GO:0003700 DNA-binding transcription factor activity increased relative to PR:000036497 hSP1/iso:1/Clv:1 PMID:11371615
enables GO:0003677 DNA binding PMID:11371615
located_in GO:0005634 nucleus PMID:11371615
PR:000036499
hSP1/iso:1/Phos:1
enables GO:0003677 DNA binding PMID:2170018
located_in GO:0005634 nucleus PMID:2170018, PMID:9525578
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036496 hSP1/iso:1/Ac:1

PMID:15647279
PR:000036497 hSP1/iso:1/Clv:1

PMID:16407261
PR:000036498 hSP1/iso:1/OGlyco:1
Ser-491, MOD:00805
PMID:11371615
PR:000036499 hSP1/iso:1/Phos:1

PMID:2170018, PMID:9525578
PR:000036500 hSP1/iso:1/Phos:2
Thr-579, MOD:00047
PMID:9153193
PR:000036501 hSP1/iso:1/Phos:3
Ser-59, MOD:00046
PMID:17049555, PMID:18239466
PR:000036502 hSP1/iso:1/Phos:4

PMID:18171990
PR:P08047-1 hSP1/iso:1

PMID:2170018

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