PRO Entry Report - PR:000000621

Protein Ontology Report - hTGFB1/var:R218C/Clv:1

PR:000000621 - http://purl.obolibrary.org/obo/PR_000000621

Protein Forms Annotations

Ontology Information

PRO ID

PR:000000621 Show OBO stanza / PAF / GPI

PRO name

TGF-beta 1 sequence variant R218C cleaved 1 (human)

Synonyms

PRO-short-label:	EXACT:	hTGFB1/var:R218C/Clv:1
PRO-proteoform-std:	EXACT:	UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950
Other:	EXACT:	TGF-beta 1 sequence variant 3 cleaved 1 (human)

Definition

A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950. [PMID:11278244, PRO:CNA, PRO:DAN]

PRO Category

organism-modification

Parent

PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000621 hTGFB1/var:R218C/Clv:1 Arg-218, CHEBI:29950	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11062463, PMID:12493741, PMID:12843182
	enables	GO:0005160 transforming growth factor beta receptor binding	PMID:11278244
	enables	GO:0042803 protein homodimerization activity	PMID:11062463, PMID:12493741, PMID:12843182
	enables	GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature	PMID:11062463, PMID:12493741, PMID:12843182
	located_in	GO:0005615 extracellular space	PMID:11062463, PMID:12493741, PMID:12843182

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000000621 hTGFB1/var:R218C/Clv:1 Arg-218, CHEBI:29950	PMID:11062463, PMID:12493741, PMID:12843182

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