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Protein Ontology Report - hTGFB1/var:R218C/Clv:1

PR:000000621 - http://purl.obolibrary.org/obo/PR_000000621
Ontology Information
PRO ID PR:000000621 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant R218C cleaved 1 (human)
Synonyms
PRO-short-label: EXACT: hTGFB1/var:R218C/Clv:1
PRO-proteoform-std: EXACT: UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950
Other: EXACT: TGF-beta 1 sequence variant 3 cleaved 1 (human)
Definition A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950. [PMID:11278244, PRO:CNA, PRO:DAN]
PRO Category organism-modification
Parent PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000621
hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950
capable_of GO:0005160 transforming growth factor beta receptor binding PMID:11278244
capable_of GO:0042803 protein homodimerization activity PMID:11062463, PMID:12493741, PMID:12843182
capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:11062463, PMID:12493741, PMID:12843182
located_in GO:0005615 extracellular space PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463, PMID:12493741, PMID:12843182
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000621 hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000000621 hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182

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