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Protein Ontology Report - hTGFB1/var:H222D/Clv:1

PR:000000623 - http://purl.obolibrary.org/obo/PR_000000623
Ontology Information
PRO ID PR:000000623 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant H222D cleaved 1 (human)
Synonyms
PRO-short-label: EXACT: hTGFB1/var:H222D/Clv:1
PRO-proteoform-std: EXACT: UniProtKB:P01137, 279-390, His-222, CHEBI:29958
Other: EXACT: TGF-beta 1 sequence variant 5 cleaved 1 (human)
Definition A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958. [PRO:CNA, PRO:DAN]
PRO Category organism-modification
Parent PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000623
hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:12493741
located_in GO:0005615 extracellular space PMID:12493741
participates_in GO:0043066 negative regulation of apoptotic process PMID:12493741
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741

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