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Protein Ontology Report - CATSPER2

PR:000000670 -
Ontology Information
PRO ID PR:000000670 Show OBO stanza / PAF
PRO name cation channel sperm-associated protein 2
PRO-short-label: EXACT: CATSPER2
Other: EXACT: CatSper2
Definition A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. [PRO:CNA]
PRO Category gene
Parent PR:000044645 CatSper channel protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 4 organism-sequence 5
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
participates_in GO:0030317 flagellated sperm motility PMID:14657366, PMID:17174296, PMID:17227845
participates_in GO:0001539 cilium or flagellum-dependent cell motility PMID:14657366
located_in GO:0031514 motile cilium PMID:11675491, PMID:14657366
capable_of GO:0005515 protein binding with PR:Q9P0X4 hCACNA1I PMID:16740636
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0005515 protein binding PR:Q96P56-1 hCATSPER2/iso:1

with PR:Q9P0X4 hCACNA1I
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030317 flagellated sperm motility PR:A2ARP9 mCATSPER2

PMID:14657366, PMID:17174296, PMID:17227845
GO:0001539 cilium or flagellum-dependent cell motility PR:A2ARP9 mCATSPER2

Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0031514 motile cilium PR:A2ARP9-1 mCATSPER2/iso:m1

PMID:11675491, PMID:14657366