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Protein Ontology Report - fam:TRPC

PR:000000680 -
Ontology Information
PRO ID PR:000000680 Show OBO stanza
PRO name transient receptor potential cation channel TRPC
PRO-short-label: EXACT: fam:TRPC
Definition A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means. [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]
PRO Category family
Parent PR:000044657 transient receptor potential channel protein
Term Hierarchy Visualization DAG     OLS     Cytoscape