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Protein Ontology Report - CNGA3

PR:000000696 - http://purl.obolibrary.org/obo/PR_000000696
Ontology Information
PRO ID PR:000000696 Show OBO stanza / PAF
PRO name cyclic nucleotide-gated cation channel alpha-3
Synonyms
PRO-short-label: EXACT: CNGA3
Gene-based: RELATED: CNCG3
Other: EXACT: CNG channel alpha-3 | CNG-3 | CNG3 | cone photoreceptor cGMP-gated channel subunit alpha | cyclic nucleotide-gated channel alpha-3
Definition A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors. [PRO:CNA]
PRO Category gene
Parent PR:000000673 cyclic nucleotide-gated channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 2 organism-sequence 12
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000748
hCNGA3/var:P163L
Pro-163, CHEBI:30006 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000743
hCNGA3/var:G557R
Gly-557, CHEBI:29952 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000742
hCNGA3/var:T291R
Thr-291, CHEBI:29952 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000741
hCNGA3/var:R283Q
Arg-283, CHEBI:30011 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000747
hCNGA3/var:R410W
Arg-410, CHEBI:29954 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000746
hCNGA3/var:F547L
Phe-547, CHEBI:30006 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000745
hCNGA3/var:R283W
Arg-283, CHEBI:29954 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:000000744
hCNGA3/var:V529M
Val-529, CHEBI:16044 		associated_with_disease_progression DOID:13911 achromatopsia PMID:9662398
PR:Q9JJZ8-1
mCNGA3/iso:m1
enables GO:0005221 intracellular cyclic nucleotide activated cation channel activity PMID:10662822
located_in GO:0001750 photoreceptor outer segment PMID:10813773, PMID:15634774
part_of GO:0032991 protein-containing complex PMID:10662822
PR:Q16281-1
hCNGA3/iso:1
acts_upstream_of_or_within GO:0007165 signal transduction PMID:9517456
enables GO:0015276 ligand-gated ion channel activity PMID:9517456
part_of GO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12467591
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0001750 photoreceptor outer segment PR:Q9JJZ8-1 mCNGA3/iso:m1

PMID:10813773, PMID:15634774

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