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Protein Ontology Report - KCNN4

PR:000000700 - http://purl.obolibrary.org/obo/PR_000000700
Ontology Information
PRO ID PR:000000700 Show OBO stanza / PAF
PRO name intermediate conductance calcium-activated potassium channel protein 4
Synonyms
PRO-short-label: EXACT: KCNN4
Gene-based: RELATED: IK1 | IKCA1 | KCA4 | SK4
Other: EXACT: IKCa1 | KCa3.1 | KCa4 | SKCa 4 | SKCa4 | putative Gardos channel
Definition A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels. [PMID:9326665, PMID:9407042]
PRO Category gene
Parent PR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 2
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:O15554
hKCNN4
acts_upstream_of_or_within GO:0006952 defense response PMID:11278890, PMID:9407042
enables GO:0005516 calmodulin binding PMID:10026195
PR:O15554-1
hKCNN4/iso:1
enables GO:0005516 calmodulin binding PMID:10026195
located_in GO:0009986 cell surface PMID:11395478
PR:O89109-1
mKCNN4/iso:1
acts_upstream_of_or_within GO:0050714 positive regulation of protein secretion PMID:11724775
enables GO:0015269 calcium-activated potassium channel activity PMID:11724775
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:O15554-1 hKCNN4/iso:1

PMID:11395478

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