PRO ID |
PR:000000700
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/ PAF
|
PRO name |
intermediate conductance calcium-activated potassium channel protein 4 |
Synonyms |
PRO-short-label: |
EXACT: |
KCNN4 |
Gene-based: |
RELATED: |
IK1 | IKCA1 | KCA4 | SK4 |
Other: |
EXACT: |
IKCa1 | KCa3.1 | KCa4 | SKCa 4 | SKCa4 | putative Gardos channel |
|
Definition |
A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels.
[PMID:9326665, PMID:9407042]
|
PRO Category |
gene |
Parent |
PR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit |
Terms by PRO Category |
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/ PAF
Organism-Independent |
Organism-Specific |
Category |
Number of Terms |
Category |
Number of Terms |
gene
|
1 |
organism-gene
|
3 |
sequence
|
1 |
organism-sequence
|
2 |
modification
|
0 |
organism-modification
|
0 |
union
|
0 |
|
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