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Protein Ontology Report - KCNV2

PR:000000726 - http://purl.obolibrary.org/obo/PR_000000726
Ontology Information
PRO ID PR:000000726 Show OBO stanza / PAF
PRO name voltage-gated potassium channel KCNV2
Synonyms
PRO-short-label: EXACT: KCNV2
Other: EXACT: voltage-gated potassium channel subunit Kv8.2
Definition A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV2 gene or a 1:1 ortholog thereof. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIS. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits. [PRO:CNA]
PRO Category gene
Parent PR:000000685 voltage-gated potassium channel alpha subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 7
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000803
hKCNV2/var:G459D
Gly-459, CHEBI:29958
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000804
hKCNV2/var:A259V
Ala-259, CHEBI:30015
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000805
hKCNV2/var:L126Q
Leu-126, CHEBI:30011
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000806
hKCNV2/var:4
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000807
hKCNV2/var:S256W
Ser-256, CHEBI:29954
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000808
hKCNV2/var:W188C
Trp-188, CHEBI:29950
associated_with_disease_progression DOID:0050795 cone dystrophy PMID:16909397
PR:000000726
KCNV2
enables GO:0015459 potassium channel regulator activity PANTHER:PTHR11537:SF40

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