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Protein Ontology Report - CD4

PR:000001004 -
Ontology Information
PRO ID PR:000001004 Show OBO stanza / PAF
PRO name CD4 molecule
PRO-short-label: EXACT: CD4
Other: EXACT: T-cell differentiation antigen L3T4 | T-cell surface antigen T4/Leu-3 | T-cell surface glycoprotein CD4
Definition A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. [PMID:15326605]
Comment Requested by=CL.
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 4 organism-modification 54
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

CD4 forms found in complexes
CD4 Component Complexes
PR:000028418 hCD4/SigPep- PR:000028449 CD4:Lck complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
acts_upstream_of_or_within GO:0090630 activation of GTPase activity PMID:9269777
enables GO:0005515 protein binding with PR:P05879 env (HIV-1 M:B_CDC-451) PMID:9269777
enables GO:0001618 virus receptor activity PMID:3259291
enables GO:0005515 protein binding with PR:000003229 env/Clv:gp120/GlycoRes+ PMID:3259291