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Protein Ontology Report - ITGAM

PR:000001012 -
Ontology Information
PRO ID PR:000001012 Show OBO stanza
PRO name integrin alpha-M
PRO-short-label: EXACT: ITGAM
Gene-based: RELATED: CD11B | CR3A
Other: EXACT: CD11 antigen-like family member B | CD11b | CR-3 alpha chain | cell surface glycoprotein MAC-1 subunit alpha | leukocyte adhesion receptor MO1 | neutrophil adherence receptor
Definition An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1. [UniProtKB:P11215]
Comment Requested by=CL.
PRO Category gene
Parent PR:000001005 integrin alpha with A domain
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 0 organism-sequence 4
modification 1 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

ITGAM forms found in complexes
ITGAM Component Complexes
PR:000027393 hITGAM/SigPep- PR:000028431 integrin alphaMbeta2:JAM3 (human)
PR:000027393 hITGAM/SigPep- PR:000027308 alphaM-beta2 integrin complex (human)