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Protein Ontology Report - EZR

PR:000001031 - http://purl.obolibrary.org/obo/PR_000001031
Ontology Information
PRO ID PR:000001031 Show OBO stanza / PAF
PRO name ezrin
Synonyms
PRO-short-label: EXACT: EZR
Gene-based: RELATED: VIL2
Other: EXACT: cytovillin | villin-2
BROAD: p81
Definition An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001030 erm protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 8
modification 9 organism-modification 9
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036589
hEZR/iso:1/Phos:2
Ser-66, MOD:00046
enables GO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590
hEZR/iso:1/Phos:3
Tyr-191, MOD:00048
enables GO:0005515 protein binding with PR:P00523-1 chick-SRC/iso:1 PMID:15647376
PR:000036625
hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047
enables GO:0003779 actin binding PMID:18852256
located_in GO:0005886 plasma membrane PMID:18852256
located_in GO:0002102 podosome PMID:18852256
PR:000036592
hEZR/iso:1/Phos:5
Thr-567, MOD:00047
acts_upstream_of_or_within GO:0001771 immunological synapse formation PMID:18025306
acts_upstream_of_or_within GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
enables GO:0005515 protein binding with PR:P43403 hZAP70 PMID:18025306
located_in GO:0045177 apical part of cell PMID:16144865
located_in GO:0001772 immunological synapse PMID:18025306
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0002102 podosome PR:000036625 hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047
PMID:18852256
GO:0045177 apical part of cell PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:16144865
GO:0005886 plasma membrane PR:000036625 hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047
PMID:18852256
GO:0001772 immunological synapse PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:18025306

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