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Protein Ontology Report - TRPV4

PR:000001068 - http://purl.obolibrary.org/obo/PR_000001068
Ontology Information
PRO ID PR:000001068 Show OBO stanza / PAF
PRO name transient receptor potential cation channel TRPV4
Synonyms
PRO-short-label: EXACT: TRPV4
Gene-based: RELATED: VRL2 | VROAC
Other: EXACT: OTRPC4 | Osm-9-like TRP channel 4 | TRP12 | TrpV4 | VR-OAC | VRL-2 | transient receptor potential protein 12 | vanilloid receptor-like channel 2 | vanilloid receptor-like protein 2 | vanilloid receptor-related osmotically-activated channel
Definition A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. [PRO:CNA, UniProtKB:Q9HBA0]
PRO Category gene
Parent PR:000000681 transient receptor potential cation channel TRPV
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 5 organism-sequence 7
modification 0 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q9HBA0-2
hTRPV4/iso:B
located_in GO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9EPK8-1
mTRPV4/iso:A
acts_upstream_of_or_within GO:0006970 response to osmotic stress PMID:11025659
acts_upstream_of_or_within GO:0007231 osmosensory signaling pathway PMID:11025659
enables GO:0005515 protein binding with PR:O88735 mMAP7 PMID:14517216
enables GO:0005262 calcium channel activity PMID:11025659
located_in GO:0005886 plasma membrane PMID:14517216
PR:Q9HBA0-1
hTRPV4/iso:A
enables GO:0042802 identical protein binding with PR:Q9HBA0-1 hTRPV4/iso:A PMID:16293632
located_in GO:0005886 plasma membrane PMID:16293632
PR:Q9HBA0-4
hTRPV4/iso:C
located_in GO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-6
hTRPV4/iso:E
located_in GO:0005783 endoplasmic reticulum PMID:16293632
PR:Q9HBA0-5
hTRPV4/iso:D
enables GO:0042802 identical protein binding with PR:Q9HBA0-5 hTRPV4/iso:D PMID:16293632
located_in GO:0005886 plasma membrane PMID:16293632
PR:Q9EPK8
mTRPV4
acts_upstream_of_or_within GO:0047484 regulation of response to osmotic stress PMID:12777254
acts_upstream_of_or_within GO:0030103 vasopressin secretion PMID:12777254
acts_upstream_of_or_within GO:0042538 hyperosmotic salinity response PMID:12777254
enables GO:0005034 osmosensor activity PMID:11025659
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:Q9EPK8-1 mTRPV4/iso:A

PMID:14517216
PR:Q9HBA0-1 hTRPV4/iso:A

PMID:16293632
PR:Q9HBA0-5 hTRPV4/iso:D

PMID:16293632
GO:0005783 endoplasmic reticulum PR:Q9HBA0-2 hTRPV4/iso:B

PMID:16293632
PR:Q9HBA0-4 hTRPV4/iso:C

PMID:16293632
PR:Q9HBA0-6 hTRPV4/iso:E

PMID:16293632

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