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Protein Ontology Report - TAB1

PR:000001770 - http://purl.obolibrary.org/obo/PR_000001770
Ontology Information
PRO ID PR:000001770 Show OBO stanza / PAF
PRO name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Synonyms
PRO-short-label: EXACT: TAB1
Gene-based: RELATED: MAP3K7IP1
Other: EXACT: TAK1-binding protein 1 | TGF-beta-activated kinase 1-binding protein 1 | mitogen-activated protein kinase kinase kinase 7-interacting protein 1
Definition A protein that is a translation product of the human TAB1 gene or a 1:1 ortholog thereof. It contains a copy of the Protein phosphatase 2C (Pfam:PF00481) domain. [PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 0 organism-sequence 2
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TAB1 forms found in complexes
TAB1 Component Complexes
PR:Q15750 hTAB1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q15750 hTAB1 PR:000035730 TAK1 kinase complex (human)
PR:Q15750 hTAB1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q15750 hTAB1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:Q15750 hTAB1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q15750 hTAB1 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8CF89 mTAB1 PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q8CF89 mTAB1 PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q8CF89 mTAB1 PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:Q8CF89 mTAB1 PR:000027102 TAK1 kinase complex (mouse)
PR:Q8CF89 mTAB1 PR:000027105 TRIKA2 complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26039
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000001770
TAB1
has_part Pfam:PF00481 Protein phosphatase 2C
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000035730
TAK1 kinase complex (human)
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
participates_in GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
located_in GO:0005829 cytosol Reactome:REACT_23131
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0004674 protein serine/threonine kinase activity PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0038095 Fc-epsilon receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_163936
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_6809
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_25222
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0034138 toll-like receptor 3 signaling pathway PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0010008 endosome membrane PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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