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Protein Ontology Report - TBK1

PR:000001779 - http://purl.obolibrary.org/obo/PR_000001779
Ontology Information
PRO ID PR:000001779 Show OBO stanza / PAF
PRO name serine/threonine-protein kinase TBK1
Synonyms
PRO-short-label: EXACT: TBK1
Gene-based: RELATED: NAK
Other: EXACT: NF-kappa-B-activating kinase | T2K | TANK-binding kinase 1
Definition An IKK-related kinase that is a translation product of the human TBK1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001777 IKK-related kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 1
modification 1 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TBK1 forms found in complexes
TBK1 Component Complexes
PR:000028695 hTBK1/Phos:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028695 hTBK1/Phos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028695 hTBK1/Phos:1 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028695 hTBK1/Phos:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000028695 hTBK1/Phos:1 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028695 hTBK1/Phos:1 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q9WUN2 mTBK1 PR:000036149 tbk1:tank:ikke complex (mouse)
PR:Q9WUN2 mTBK1 PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q9WUN2 mTBK1 PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:Q9WUN2 mTBK1 PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q9WUN2 mTBK1 PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036149
tbk1:tank:ikke complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:17823124
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000036123
p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26959
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000037313
tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:12133833, PMID:17327220
PR:000037322
p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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