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Protein Ontology Report - IRAK1

PR:000001782 - http://purl.obolibrary.org/obo/PR_000001782
Ontology Information
PRO ID PR:000001782 Show OBO stanza / PAF
PRO name interleukin-1 receptor-associated kinase 1
Synonyms
PRO-short-label: EXACT: IRAK1
Gene-based: RELATED: IRAK | Il1rak
Other: EXACT: IRAK-1
Definition An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001781 interleukin-1 receptor-associated kinase IRAK1/3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 6
modification 5 organism-modification 8
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRAK1 forms found in complexes
IRAK1 Component Complexes
PR:000027178 mIRAK1/iso:1/Phos:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027179 mIRAK1/iso:1/UnMod PR:000027253 IRAK1:tollip complex (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:Q62406 mIRAK1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027494
hIRAK1/iso:1/Phos:1
Thr-209, MOD:00047
capable_of GO:0016301 kinase activity PMID:11960013
capable_of GO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027493
hIRAK1/iso:1/Phos:4
Thr-209/Thr-387, MOD:00047|MOD:00046
capable_of GO:0004674 protein serine/threonine kinase activity PMID:14625308
capable_of GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308
capable_of NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
PR:000027492
hIRAK1/iso:1/Phos:3
Thr-209/Thr-387, MOD:00047
capable_of GO:0004674 protein serine/threonine kinase activity PMID:14625308
participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
PR:P51617-1
hIRAK1/iso:1
capable_of GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
capable_of GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308
participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0070498 interleukin-1-mediated signaling pathway PR:000027492 hIRAK1/iso:1/Phos:3
Thr-209/Thr-387, MOD:00047
PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
Thr-209/Thr-387, MOD:00047|MOD:00046
PMID:14625308
PR:P51617-1 hIRAK1/iso:1

PMID:14625308
GO:0034142 toll-like receptor 4 signaling pathway PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894

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