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Protein Ontology Report - IRF3

PR:000002045 - http://purl.obolibrary.org/obo/PR_000002045
Ontology Information
PRO ID PR:000002045 Show OBO stanza / PAF
PRO name interferon regulatory factor 3
Synonyms
PRO-short-label: EXACT: IRF3
Other: EXACT: IRF-3
Definition An interferon regulatory factor 3-9 that is a translation product of the human IRF3 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000001863 interferon regulatory factor 3-9
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 7
modification 3 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRF3 forms found in complexes
IRF3 Component Complexes
PR:000025763 hIRF3/iso:1/Phos:1 PR:000036002 IRF3-P:IRF3-P:KPNA4 complex (human)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000036043 IRF3-P:p65 complex (mouse)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000027098 IRF3-P:IRF3-P complex (mouse)
PR:000027097 mIRF3/iso:1/Phos:1 PR:000036047 IRF3-P:p65:ISRE complex (mouse)
PR:000028702 hIRF3/UnMod PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028702 hIRF3/UnMod PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000028702 hIRF3/UnMod PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000028702 hIRF3/UnMod PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000045488 hIRF3/Phos:1 PR:000025765 IRF3-P:IRF3-P complex (human)
PR:000045489 hIRF3/iso:1/Phos:2 PR:000027084 IRF3-P:IRF7-P complex (human)
PR:Q14653 hIRF3 PR:000036045 IRF3:XPO1 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036043
IRF3-P:p65 complex (mouse)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:14557267
located_in GO:0005634 nucleus PMID:14557267
PR:000036045
IRF3:XPO1 complex (human)
located_in GO:0005737 cytoplasm PMID:10805757
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000025765
IRF3-P:IRF3-P complex (human)
acts_upstream_of_or_within GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus Reactome:REACT_7146
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0034340 response to type I interferon PMID:10805757
located_in GO:0005829 cytosol Reactome:REACT_7146
located_in GO:0005634 nucleus PMID:10805757
located_in GO:0005654 nucleoplasm Reactome:REACT_7444
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000025763
hIRF3/iso:1/Phos:1
Ser-385/Ser-386, MOD:00046
enables GO:0005515 protein binding with PR:O14980 hXPO1 PMID:10805757
located_in GO:0005829 cytosol Reactome:REACT_7149
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:P70671-1
mIRF3/iso:1
located_in GO:0005737 cytoplasm MGI:3828224, PMID:18851954
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000025763 hIRF3/iso:1/Phos:1
Ser-385/Ser-386, MOD:00046
Reactome:REACT_7149
PR:000025765 IRF3-P:IRF3-P complex (human)

Reactome:REACT_7146
GO:0005654 nucleoplasm PR:000025765 IRF3-P:IRF3-P complex (human)

Reactome:REACT_7444
GO:0010008 endosome membrane PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0005634 nucleus PR:000025765 IRF3-P:IRF3-P complex (human)

PMID:10805757
PR:000036043 IRF3-P:p65 complex (mouse)

PMID:14557267
GO:0005737 cytoplasm PR:000036045 IRF3:XPO1 complex (human)

PMID:10805757
PR:P70671-1 mIRF3/iso:1

MGI:3828224, PMID:18851954

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