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Protein Ontology Report - AKT1

PR:000002190 - http://purl.obolibrary.org/obo/PR_000002190
Ontology Information
PRO ID PR:000002190 Show OBO stanza / PAF
PRO name RAC-alpha serine/threonine-protein kinase
Synonyms
PRO-short-label: EXACT: AKT1
Gene-based: RELATED: Akt | RAC
BROAD: PKB
Other: EXACT: AKT1 kinase | PKB alpha | RAC-PK-alpha | protein kinase B | protein kinase B alpha | proto-oncogene c-Akt | thymoma viral proto-oncogene
Definition An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000029189 AKT kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 5 organism-modification 9
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000028994
hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
acts_upstream_of_or_within GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
acts_upstream_of_or_within GO:0032869 cellular response to insulin stimulus PMID:8978681
enables GO:0004672 protein kinase activity PMID:8978681
enables GO:0005515 protein binding with PR:P41279-1 hMAP3K8/iso:1 PMID:12138205
enables GO:0005515 protein binding with PR:O14746-1 hTERT/iso:1 PMID:12586360
enables GO:0004674 protein serine/threonine kinase activity PMID:12138205
PR:000027473
hAKT1/iso:1/Phos:2
Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:16549426

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