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Protein Ontology Report - LY96

PR:000003296 - http://purl.obolibrary.org/obo/PR_000003296
Ontology Information
PRO ID PR:000003296 Show OBO stanza / PAF
PRO name lymphocyte antigen 96
Synonyms
PRO-short-label: EXACT: LY96
Gene-based: RELATED: ESOP1 | MD2
Other: EXACT: ESOP-1 | ly-96 | protein MD-2
Definition A protein that is a translation product of the human LY96 gene or a 1:1 ortholog thereof. [TLR:AMM]
Comment Requested by=TLR.
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 3 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

LY96 forms found in complexes
LY96 Component Complexes
PR:000003296 LY96 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000003296 LY96 PR:000036076 activated TLR4 complex
PR:000003296 LY96 PR:000036003 LY96:TLR4 complex
PR:000003296 LY96 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000003299 LY96/iso:1/SigPep-/NGlyco:1 PR:000025498 lipopolysaccharide receptor complex 4
PR:000003299 LY96/iso:1/SigPep-/NGlyco:1 PR:000025497 lipopolysaccharide receptor complex 3
PR:000003299 LY96/iso:1/SigPep-/NGlyco:1 PR:000025496 lipopolysaccharide receptor complex 2
PR:000003299 LY96/iso:1/SigPep-/NGlyco:1 PR:000025495 lipopolysaccharide receptor complex 1
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000044684 activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000028678 ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036004 LY96:TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1 PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027204 ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036077 activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000036005 LY96:TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000037794 MD2:GB4:TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:A0A1D5NZX9 chick-LY96 PR:000037474 activated TLR4 complex (chicken)
PR:A0A1D5NZX9 chick-LY96 PR:000037473 LY96:TLR4 complex (chicken)
PR:A0A1D5NZX9 chick-LY96 PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037794
MD2:GB4:TLR4 complex (mouse)
acts_upstream_of_or_within GO:0034144 negative regulation of toll-like receptor 4 signaling pathway PMID:23471986
enables NOT GO:0001530 lipopolysaccharide binding PMID:23471986
PR:000025773
lipopolysaccharide receptor complex 3 (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037476
lipopolysaccharide receptor complex 3 (mouse)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:12196527
PR:000037475
MYD88:TIRAP:activated TLR4 receptor (chicken)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25089
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_25089
located_in GO:0005886 plasma membrane Reactome:REACT_26615
PR:000037474
activated TLR4 complex (chicken)
acts_upstream_of_or_within GO:0051607 defense response to virus PMID:24034933
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18768894
acts_upstream_of_or_within GO:0045429 positive regulation of nitric oxide biosynthetic process PMID:24034933
located_in GO:0005886 plasma membrane Reactome:REACT_25442
PR:000037473
LY96:TLR4 complex (chicken)
acts_upstream_of_or_within NOT GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18768894
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18768894
located_in GO:0005886 plasma membrane Reactome:REACT_26915
PR:000025786
hLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114, MOD:00160 		enables GO:1990458 lipooligosaccharide binding PMID:19783674
enables GO:0001530 lipopolysaccharide binding PMID:17569869
located_in GO:0005886 plasma membrane Reactome:REACT_7660
located_in GO:0005615 extracellular space PMID:19783674
located_in GO:0005615 extracellular space PMID:11593030
PR:000027208
ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_7861
PR:000036005
LY96:TLR4 complex (mouse)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:17803912
PR:000036004
LY96:TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_in GO:0005886 plasma membrane Reactome:REACT_7105
PR:000036060
pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344
located_in GO:0010008 endosome membrane Reactome:REACT_151344
PR:000027204
ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18222170
located_in GO:0010008 endosome membrane PMID:18222170
PR:000027207
ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18222170
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18222170
located_in GO:0010008 endosome membrane PMID:18222170
PR:000036027
sarm:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758
located_in GO:0010008 endosome membrane Reactome:REACT_151758
PR:000036123
p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26959
PR:000036024
rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25948
PR:000036101
rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26039
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
PR:000028680
traf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25948
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
enables GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
PR:000035710
traf6:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:14530355
PR:000036041
K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_124855
PR:000035715
pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25867
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
located_in GO:0005886 plasma membrane Reactome:REACT_125282
PR:000036124
p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26959
PR:000028678
ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_7083
PR:000027171
mLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114/Asn-150, MOD:00160 		enables NOT GO:1990458 lipooligosaccharide binding PMID:19783674
located_in GO:0005615 extracellular space PMID:19783674
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
enables GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
acts_upstream_of_or_within GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
PR:000036056
rip3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_152149
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26016
PR:000036135
TIRAP:PIP2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
located_in GO:0005886 plasma membrane Reactome:REACT_152404
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000036058
rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_151344
PR:000036077
activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:23565187
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000036049
K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_25755
PR:Q9JHF9
mLY96
enables GO:0005515 protein binding with PR:O35716 mSOCS1 PMID:19296467
PR:000027196
TIRAP:PIP2:activated TLR4 (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000028683
traf3:ticam1:ticam2:activated TLR4 complex (mouse)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:16306937
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:16306937
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
enables GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114, MOD:00160
Reactome:REACT_7660
PR:000036004 LY96:TLR4 complex (human)

Reactome:REACT_7105
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_152404
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037473 LY96:TLR4 complex (chicken)

Reactome:REACT_26915
PR:000037474 activated TLR4 complex (chicken)

Reactome:REACT_25442
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_26615
GO:0010008 endosome membrane PR:000027204 ticam2:activated TLR4 complex (mouse)

PMID:18222170
PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)

PMID:18222170
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_7861
PR:000028678 ticam2:activated TLR4 complex (human)

Reactome:REACT_7083
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25867
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151758
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124855
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25755
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_152149
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_151344
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
GO:0005615 extracellular space PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114, MOD:00160
PMID:19783674
PR:000025786 hLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114, MOD:00160
PMID:11593030
PR:000027171 mLY96/iso:1/SigPep-/NGlyco:1
Asn-26/Asn-114/Asn-150, MOD:00160
PMID:19783674

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