back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - BUB1

PR:000004854 - http://purl.obolibrary.org/obo/PR_000004854
Ontology Information
PRO ID PR:000004854 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms
PRO-short-label: EXACT: BUB1
Gene-based: RELATED: BUB1L
Other: EXACT: BUB1A
Definition A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof. [PMID:22698286, PRO:CNA]
PRO Category gene
Parent PR:000035665 BUB1/BUB1B protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 6
sequence 0 organism-sequence 6
modification 9 organism-modification 18
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

BUB1 forms found in complexes
BUB1 Component Complexes
PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)
PR:O43683 hBUB1 PR:000035564 BUB1:BUB3 complex (human)
PR:O43683 hBUB1 PR:000035576 BUB1:BUB3:APC complex (human)
PR:O43683 hBUB1 PR:000035567 BUB1:BUB3:MAD1L1 complex (human)
PR:O43683 hBUB1 PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:O43683 hBUB1 PR:000035577 BUB1:phosphoBUB1B complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:O08901
mBUB1
acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499
located_in GO:0000775 chromosome, centromeric region PMID:19965387
PR:O43683
hBUB1
acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:19252416
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15525512
acts_upstream_of_or_within GO:0007062 sister chromatid cohesion PMID:16580887
acts_upstream_of_or_within GO:0043069 negative regulation of programmed cell death PMID:20057499
acts_upstream_of_or_within GO:0007059 chromosome segregation PMID:16580887
acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16760428
acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:16580887
acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
acts_upstream_of_or_within GO:0071459 protein localization to chromosome, centromeric region PMID:21658950
enables GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-723200
enables GO:0004672 protein kinase activity PMID:10198256
enables GO:0005515 protein binding with PR:P53350 hPLK1 BioGRID:BG-718371
enables GO:0005515 protein binding with PR:O43684 hBUB3 PMID:10198256, PMID:15525512
enables GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302960
enables GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:19252416
enables GO:0005515 protein binding with PR:O60566 hBUB1B PMID:11792804
enables GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 PMID:10198256
located_in GO:0000776 kinetochore PMID:20624902
located_in GO:0000939 inner kinetochore PMID:11792804
located_in GO:0000940 outer kinetochore PMID:11792804, PMID:16760428
PR:Q98UH3
frog-BUB1/var:1
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:12163471
enables GO:0005515 protein binding with PR:Q9YGY3 frog-BUB3 PMID:11231148
located_in GO:0005694 chromosome PMID:15241477, PMID:16950116
located_in GO:0000776 kinetochore PMID:11231148, PMID:12163471
PR:000035419
yBUB1/Phos:CDK-1
Thr-566, MOD:00047
acts_upstream_of_or_within NOT GO:0031577 spindle checkpoint signaling PMID:21298086
PR:000029911
frog-BUB1/Phos:1
enables GO:0016301 kinase activity increased relative to PR:000029917 frog-BUB1/PhosRes- PMID:11231148
PR:000035421
hBUB1/Phos:10
Ser-314, MOD:00046
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:22099307
acts_upstream_of_or_within GO:0006281 DNA repair PMID:22071147
enables GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:22071147
located_in GO:0035861 site of double-strand break PMID:22071147
PR:000035412
hBUB1/Phos:7
Ser-593, MOD:00046|Thr-609, MOD:00047
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428
enables GO:0005515 protein binding increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP PMID:16760428
PR:000035411
Spom972h-BUB1/Phos:6
acts_upstream_of_or_within GO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
acts_upstream_of_or_within GO:0045143 homologous chromosome segregation PMID:12606573
located_in GO:0000776 kinetochore PMID:12606573
PR:000035410
Spom972h-BUB1/Phos:5
acts_upstream_of_or_within GO:0007094 mitotic spindle assembly checkpoint signaling PMID:12606573
acts_upstream_of_or_within GO:0045143 homologous chromosome segregation PMID:12606573
PR:000035404
frog-BUB1/Phos:3
Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15241477
enables GO:0004672 protein kinase activity increased relative to PR:000029917 frog-BUB1/PhosRes- PMID:15241477
PR:000035405
hBUB1/PhosRes-
enables NOT GO:0005515 protein binding with PR:P53350 hPLK1 PMID:16760428
located_in GO:0000776 kinetochore PMID:16760428
PR:000035407
hBUB1/Phos:4
enables GO:0004672 protein kinase activity increased relative to PR:000035405 hBUB1/PhosRes- PMID:15525512
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000940 outer kinetochore PR:O43683 hBUB1

PMID:11792804, PMID:16760428
GO:0035861 site of double-strand break PR:000035421 hBUB1/Phos:10
Ser-314, MOD:00046
PMID:22071147
GO:0000939 inner kinetochore PR:O43683 hBUB1

PMID:11792804
GO:0000776 kinetochore PR:000035405 hBUB1/PhosRes-

PMID:16760428
PR:000035411 Spom972h-BUB1/Phos:6

PMID:12606573
PR:O43683 hBUB1

PMID:20624902
PR:Q98UH3 frog-BUB1/var:1

PMID:11231148, PMID:12163471
GO:0005694 chromosome PR:Q98UH3 frog-BUB1/var:1

PMID:15241477, PMID:16950116
GO:0000775 chromosome, centromeric region PR:O08901 mBUB1

PMID:19965387

top