back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - BUB1B

PR:000004855 - http://purl.obolibrary.org/obo/PR_000004855
Ontology Information
PRO ID PR:000004855 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Synonyms
PRO-short-label: EXACT: BUB1B
Gene-based: RELATED: BUBR1 | MAD3L | SSK1
Other: EXACT: BubR1 | MAD3/BUB1-related protein kinase | mitotic checkpoint kinase MAD3L | protein SSK1
Definition A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof. [PMID:22698286, PRO:CNA]
PRO Category gene
Parent PR:000035665 BUB1/BUB1B protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 3
modification 6 organism-modification 10
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

BUB1B forms found in complexes
BUB1B Component Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O60566 hBUB1B PR:000035563 BUB1B:BUB3 complex (human)
PR:O60566 hBUB1B PR:000035575 BUB1B:CDC20 complex (human)
PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:Q8JGT8 frog-BUB1B PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:Q8JGT8 frog-BUB1B PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035432
hBUB1B/Phos:3
Thr-608, MOD:00047
located_in GO:0000776 kinetochore PMID:22801780
participates_in GO:0031577 spindle checkpoint signaling increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0001933 negative regulation of protein phosphorylation decreased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0007059 chromosome segregation increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
PR:Q800D4
chick-BUB1B
located_in GO:0000776 kinetochore PMID:17276342
PR:Q8JGT8
frog-BUB1B
capable_of GO:0004672 protein kinase activity PMID:12163471
capable_of GO:0005515 protein binding with PR:O42263 frog-CENPE PMID:17709426
capable_of GO:0005515 protein binding with PR:Q9YGY3 frog-BUB3 PMID:12163471
capable_of GO:0005515 protein binding with PR:P79935 frog-MAD2L1 PMID:12163471
capable_of GO:0005515 protein binding with PR:P70039 frog-APC PMID:17709426
capable_of GO:0005515 protein binding with PR:Q6DFD4 frog-CDC20 PMID:12163471
located_in GO:0005694 chromosome PMID:15241477, PMID:16950116
located_in GO:0000776 kinetochore PMID:12163471, PMID:17709426
participates_in GO:0034501 protein localization to kinetochore PMID:12163471
participates_in GO:0034501 protein localization to kinetochore PMID:12163471
participates_in GO:0034501 protein localization to kinetochore PMID:12163471
participates_in GO:0031577 spindle checkpoint signaling PMID:12163471
participates_in GO:0034501 protein localization to kinetochore PMID:12163471
participates_in GO:0032092 positive regulation of protein binding PMID:12163471
participates_in GO:0032092 positive regulation of protein binding PMID:12163471
participates_in GO:0034501 protein localization to kinetochore PMID:12163471
participates_in GO:0034501 protein localization to kinetochore PMID:17709426
participates_in GO:0051310 metaphase plate congression PMID:17709426
PR:000035426
frog-BUB1B/Phos:1
Thr-605, MOD:00047
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:P70032 frog-plk1 PMID:17998400
participates_in GO:0034501 protein localization to kinetochore PMID:17998400
participates_in GO:0034501 protein localization to kinetochore PMID:17998400
participates_in GO:0031577 spindle checkpoint signaling PMID:17998400
PR:000035430
frog-BUB1B/Phos:2
Thr-605, MOD:00047|MOD:00696
capable_of GO:0004672 protein kinase activity increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17998400
PR:000035362
hBUB1B/Phos:1
Thr-620, MOD:00047
capable_of GO:0005515 protein binding increased relative to PR:000035373 hBUB1B/PhosRes- with PR:P53350 hPLK1 PMID:17785528
PR:000035398
BUB1B:APC:EB1 complex (frog)
participates_in GO:0051310 metaphase plate congression PMID:17709426
PR:000035373
hBUB1B/PhosRes-
capable_of GO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_in GO:0005813 centrosome PMID:19503101
located_in GO:0000776 kinetochore PMID:22801780
participates_in GO:0001933 negative regulation of protein phosphorylation PMID:22801780
participates_in GO:0033673 negative regulation of kinase activity PMID:19503101
participates_in GO:0010826 negative regulation of centrosome duplication PMID:19503101
PR:O60566
hBUB1B
capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
capable_of GO:0016301 kinase activity PMID:11030144
capable_of GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-715437
capable_of GO:0005515 protein binding with PR:Q9H4B4 hPLK3 PMID:15190214
capable_of GO:0005515 protein binding with PR:Q15013 hMAD2L1BP BioGRID:BG-719779
capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
capable_of GO:0005515 protein binding with PR:Q9UJX3 hANAPC7 BioGRID:BG-316229
capable_of GO:0005515 protein binding with PR:P09874 hPARP1 BioGRID:BG-480411
capable_of GO:0005515 protein binding with PR:Q02224 hCENPE PMID:17785528
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11792804
capable_of GO:0005515 protein binding with PR:Q13042 hCDC16 PMID:11030144
capable_of GO:0005515 protein binding with PR:Q92769 hHDAC2 MINT:MINT-7302197
capable_of GO:0005515 protein binding with PR:Q13547 hHDAC1 MINT:MINT-7302173
capable_of GO:0005515 protein binding with PR:O95997 hPTTG1 BioGRID:BG-721860
capable_of GO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 PMID:11030144
capable_of GO:0005515 protein binding with PR:O15379 hHDAC3 MINT:MINT-7302235
capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:20624902
capable_of GO:0005515 protein binding with PR:Q96GD4 hAURKB BioGRID:BG-717911
capable_of GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-717441
capable_of GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- PMID:11030144
capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428, PMID:17785528
capable_of GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:17671183
capable_of GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-697203
capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302963
capable_of GO:0005515 protein binding with PR:Q9UJX5 hANAPC4 BioGRID:BG-682429
capable_of GO:0005515 protein binding with PR:P04049 hRAF1 PMID:20703093
capable_of GO:0005515 protein binding with PR:P63010 hAP2B1 BioGRID:BG-283405
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:20016069
capable_of GO:0005515 protein binding with PR:O76070 hSNCG BioGRID:BG-253351
capable_of GO:0005515 protein binding with PR:P51587 hBRCA2 PMID:10749118
capable_of GO:0005515 protein binding with PR:Q96IF1 hAJUBA BioGRID:BG-717913
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144, PMID:20624902
capable_of GO:0005515 protein binding with PR:Q92831 hKAT2B MINT:MINT-7299740
located_in GO:0000922 spindle pole PMID:15190214
located_in GO:0000940 outer kinetochore PMID:11792804
located_in GO:0005737 cytoplasm PMID:10749118
located_in GO:0000776 kinetochore PMID:12719470, PMID:16760428
located_in GO:0000939 inner kinetochore PMID:11792804
participates_in GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
participates_in GO:0006469 negative regulation of protein kinase activity PMID:15592459
participates_in GO:0031647 regulation of protein stability PMID:17671183
participates_in NOT GO:0034501 protein localization to kinetochore PMID:16760428
participates_in GO:0031577 spindle checkpoint signaling PMID:11030144
participates_in GO:0051310 metaphase plate congression PMID:12719470, PMID:15592459
PR:000035435
hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
located_in GO:0000776 kinetochore PMID:19015317
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317, PMID:20016069
PR:000035428
hBUB1B/Phos:2
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:O43683 hBUB1 PMID:11792804
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:Q15172 hPPP2R5A PMID:23079597
capable_of GO:0004672 protein kinase activity increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
located_in GO:0000776 kinetochore PMID:17785528
participates_in GO:0006974 cellular response to DNA damage stimulus PMID:18440313
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779, PMID:17785528
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0033673 negative regulation of kinase activity PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0006469 negative regulation of protein kinase activity PR:O60566 hBUB1B

PMID:15592459
GO:0001933 negative regulation of protein phosphorylation PR:000035373 hBUB1B/PhosRes-

PMID:22801780
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
decreased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
GO:0006974 cellular response to DNA damage stimulus PR:000035428 hBUB1B/Phos:2

PMID:18440313
NOT GO:0034501 protein localization to kinetochore PR:O60566 hBUB1B

PMID:16760428
GO:0031647 regulation of protein stability PR:O60566 hBUB1B

PMID:17671183
GO:0032092 positive regulation of protein binding PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:12163471
GO:0007059 chromosome segregation PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
GO:0008608 attachment of spindle microtubules to kinetochore PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17785528
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:19015317, PMID:20016069
GO:0051444 negative regulation of ubiquitin-protein transferase activity PR:O60566 hBUB1B

PMID:15525512
PR:O60566 hBUB1B

PMID:15525512
GO:0034501 protein localization to kinetochore PR:000035426 frog-BUB1B/Phos:1
Thr-605, MOD:00047
PMID:17998400
PR:000035426 frog-BUB1B/Phos:1
Thr-605, MOD:00047
PMID:17998400
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:12163471
PR:Q8JGT8 frog-BUB1B

PMID:17709426
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PR:O60566 hBUB1B

PMID:15592459
GO:0010826 negative regulation of centrosome duplication PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0031577 spindle checkpoint signaling PR:000035426 frog-BUB1B/Phos:1
Thr-605, MOD:00047
PMID:17998400
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:O60566 hBUB1B

PMID:11030144
PR:Q8JGT8 frog-BUB1B

PMID:12163471
GO:0051310 metaphase plate congression PR:000035398 BUB1B:APC:EB1 complex (frog)

PMID:17709426
PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17376779, PMID:17785528
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:20016069
PR:O60566 hBUB1B

PMID:12719470, PMID:15592459
PR:Q8JGT8 frog-BUB1B

PMID:17709426
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000940 outer kinetochore PR:O60566 hBUB1B

PMID:11792804
GO:0005813 centrosome PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0005737 cytoplasm PR:O60566 hBUB1B

PMID:10749118
GO:0000939 inner kinetochore PR:O60566 hBUB1B

PMID:11792804
GO:0000776 kinetochore PR:000035373 hBUB1B/PhosRes-

PMID:22801780
PR:000035428 hBUB1B/Phos:2

PMID:17785528
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
PMID:22801780
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
PMID:19015317
PR:O60566 hBUB1B

PMID:12719470, PMID:16760428
PR:Q800D4 chick-BUB1B

PMID:17276342
PR:Q8JGT8 frog-BUB1B

PMID:12163471, PMID:17709426
GO:0005694 chromosome PR:Q8JGT8 frog-BUB1B

PMID:15241477, PMID:16950116
GO:0000922 spindle pole PR:O60566 hBUB1B

PMID:15190214

top