Protein Ontology Report - DNMT1 PR:000006606 - http://purl.obolibrary.org/obo/PR_000006606

Ontology Information
PRO ID	PR:000006606 Show OBO stanza / PAF
PRO name	DNA (cytosine-5)-methyltransferase 1
Synonyms	PRO-short-label: EXACT: DNMT1 Gene-based: RELATED: AIM | CXXC9 | DNMT | Met1 | Uim Other: EXACT: CXXC-type zinc finger protein 9 | DNA MTase HsaI | DNA MTase MmuI | DNA methyltransferase HsaI | DNA methyltransferase MmuI | Dnmt1 | M.HsaI | M.MmuI | MCMT | met-1
Definition	A protein that is a translation product of the human DNMT1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category	gene
Parent	PR:000000001 protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms gene 1 organism-gene 4 sequence 0 organism-sequence 14 modification 0 organism-modification 3 union 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	IUPHARobj:2605

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All gene organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

DNMT1 forms found in complexes
DNMT1 Component Complexes PR:000037504 hDNMT1/UnPhos:1 PR:000037517 DNMT1:PCNA:UHRF1 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037506 hDNMT1/Phos:2 Ser-127/Ser-143, MOD:00046 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874 PR:000037505 hDNMT1/Phos:1 Ser-127, MOD:00046 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874 PR:000037504 hDNMT1/UnPhos:1 Ser-127/Ser-143, PR:000026291 enables GO:0005515 protein binding with PR:Q96T88 hUHRF1 PMID:20613874 enables GO:0005515 protein binding with PR:P12004 hPCNA PMID:20613874 PR:000037517 DNMT1:PCNA:UHRF1 complex (human) associated_with_disease_suppression DOID:162 cancer PMID:20613874

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