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Protein Ontology Report - MAD2L1

PR:000010038 - http://purl.obolibrary.org/obo/PR_000010038
Ontology Information
PRO ID PR:000010038 Show OBO stanza / PAF
PRO name mitotic spindle assembly checkpoint protein MAD2A
Synonyms
PRO-short-label: EXACT: MAD2L1
Gene-based: RELATED: MAD2 | Mad2a
Other: EXACT: MAD2-like protein 1 | mitotic arrest deficient 2-like protein 1
Definition A protein that is a translation product of the human MAD2L1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 8
sequence 1 organism-sequence 4
modification 1 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

MAD2L1 forms found in complexes
MAD2L1 Component Complexes
PR:000042259 hMAD2L1/InitMet- PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:O14417 Spom972h-MAD2L1 PR:000035574 MAD2:MAD3 complex (Schizosaccharomyces pombe 972h-)
PR:P79935 frog-MAD2L1 PR:000035512 BUB1B:BUB3:MAD2:CDC20 complex (frog)
PR:Q13257 hMAD2L1 PR:000035568 MAD1:MAD2 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:P40958
yMAD2L1
acts_upstream_of_or_within GO:0006974 cellular response to DNA damage stimulus PMID:15514023
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:17504936
PR:Q13257
hMAD2L1
acts_upstream_of_or_within GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
acts_upstream_of_or_within NOT GO:0051310 metaphase plate congression PMID:15592459
enables GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302957
enables GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:20624902
enables GO:0005515 protein binding with PR:Q9Y6D9 hMAD1L1 BioGRID:BG-718929, MINT:MINT-8289277
enables GO:0005515 protein binding with PR:O60566 hBUB1B PMID:20624902
enables GO:0005515 protein binding with PR:O43684 hBUB3 BioGRID:BG-718926
enables GO:0031625 ubiquitin protein ligase binding PMID:20624902
enables GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
located_in GO:0000776 kinetochore PMID:12719470
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:Q13257 hMAD2L1

PMID:12719470

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