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Protein Ontology Report - PLK1

PR:000012870 - http://purl.obolibrary.org/obo/PR_000012870
Ontology Information
PRO ID PR:000012870 Show OBO stanza / PAF
PRO name serine/threonine-protein kinase PLK1
Synonyms
PRO-short-label: EXACT: PLK1
Gene-based: RELATED: PLK
Other: EXACT: PLK-1 | Polo-like kinase 1 | STPK13
RELATED: serine/threonine-protein kinase 13
Definition A protein that is a translation product of the human PLK1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 2
modification 1 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

PLK1 forms found in complexes
PLK1 Component Complexes
PR:P53350 hPLK1 PR:000035581 phosphoBUB1:PLK1 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000044818
hPLK1/Phos:1
Ser-99, MOD:00046|Thr-210, MOD:00047
acts_upstream_of_or_within GO:0007091 metaphase/anaphase transition of mitotic cell cycle PMID:23695676
enables GO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG PMID:23695676
PR:P53350
hPLK1
acts_upstream_of_or_within GO:0034092 negative regulation of maintenance of sister chromatid cohesion PMID:16580887
acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:16760428
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428
acts_upstream_of_or_within NOT GO:0031577 spindle checkpoint signaling PMID:16760428
acts_upstream_of_or_within GO:0051310 metaphase plate congression PMID:17376779
acts_upstream_of_or_within GO:0008608 attachment of spindle microtubules to kinetochore PMID:17376779
acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:16760428
enables GO:0005515 protein binding with PR:Q5FBB7 hSGO1 BioGRID:BG-338598
enables GO:0005515 protein binding with PR:O60566 hBUB1B PMID:17376779
enables GO:0005515 protein binding with PR:O43683 hBUB1 BioGRID:BG-718371
enables GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832
enables GO:0004672 protein kinase activity PMID:16760428
located_in GO:0005813 centrosome PMID:16760428
located_in GO:0000940 outer kinetochore PMID:16760428
located_in GO:0000922 spindle pole PMID:20823832
located_in GO:0000776 kinetochore PMID:20624902
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000940 outer kinetochore PR:P53350 hPLK1

PMID:16760428
GO:0005813 centrosome PR:P53350 hPLK1

PMID:16760428
GO:0000922 spindle pole PR:P53350 hPLK1

PMID:20823832
GO:0000776 kinetochore PR:P53350 hPLK1

PMID:20624902

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