PRO Entry Report - PR:000012870

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000012870 Show OBO stanza / PAF

PRO name

serine/threonine-protein kinase PLK1

Synonyms

PRO-short-label:	EXACT:	PLK1
Gene-based:	RELATED:	PLK
Other:	EXACT:	PLK-1 \| Polo-like kinase 1 \| STPK13
	RELATED:	serine/threonine-protein kinase 13

Definition

A protein that is a translation product of the human PLK1 gene or a 1:1 ortholog thereof. [PRO:DNx]

PRO Category

gene

Parent

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	IUPHARobj:2168

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

PLK1 forms found in complexes

PLK1 Component	Complexes
PR:P53350 hPLK1	PR:000035581 phosphoBUB1:PLK1 complex (human)

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000044818 hPLK1/Phos:1 Ser-99, MOD:00046\|Thr-210, MOD:00047	acts_upstream_of_or_within	GO:0007091 metaphase/anaphase transition of mitotic cell cycle	PMID:23695676
	enables	GO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG	PMID:23695676
PR:P53350 hPLK1	acts_upstream_of_or_within	GO:0034092 negative regulation of maintenance of sister chromatid cohesion	PMID:16580887
	acts_upstream_of_or_within	NOT GO:0034501 protein localization to kinetochore	PMID:16760428
	acts_upstream_of_or_within	NOT GO:0034501 protein localization to kinetochore	PMID:16760428
	acts_upstream_of_or_within	GO:0034501 protein localization to kinetochore	PMID:16760428
	acts_upstream_of_or_within	NOT GO:0031577 spindle checkpoint signaling	PMID:16760428
	acts_upstream_of_or_within	GO:0051310 metaphase plate congression	PMID:17376779
	acts_upstream_of_or_within	GO:0008608 attachment of spindle microtubules to kinetochore	PMID:17376779
	enables	GO:0005515 protein binding with PR:O14641 hDVL2	PMID:20823832
	enables	GO:0005515 protein binding with PR:Q5FBB7 hSGO1	BioGRID:BG-338598
	enables	GO:0005515 protein binding with PR:O60566 hBUB1B	PMID:17376779
	enables	GO:0005515 protein binding with PR:O43683 hBUB1	BioGRID:BG-718371
	enables	GO:0004672 protein kinase activity	PMID:16760428
	located_in	GO:0000776 kinetochore	PMID:20624902
	located_in	GO:0005813 centrosome	PMID:16760428
	located_in	GO:0000922 spindle pole	PMID:20823832
	located_in	GO:0000940 outer kinetochore	PMID:16760428

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