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Protein Ontology Report - TTK

PR:000016787 - http://purl.obolibrary.org/obo/PR_000016787
Ontology Information
PRO ID PR:000016787 Show OBO stanza / PAF
PRO name dual specificity protein kinase TTK
Synonyms
PRO-short-label: EXACT: TTK
Gene-based: RELATED: MPS1 | MPS1L1
Other: EXACT: ESK | Monopolar spindle protein 1 | PYT | Regulatory cell proliferation kinase 1 | phosphotyrosine picked threonine-protein kinase
RELATED: RPK1 | serine/threonine-protein kinase MPS1
Definition A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 4
modification 0 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000045754
hTTK/Phos:1
Thr-676, MOD:00047
acts_upstream_of_or_within GO:0071174 mitotic spindle checkpoint signaling PMID:18083840
acts_upstream_of_or_within GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
acts_upstream_of_or_within GO:0051298 centrosome duplication PMID:17728254
enables GO:0004672 protein kinase activity PMID:18680479
PR:000049844
hTTK/pActloop
acts_upstream_of_or_within GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
enables GO:0004672 protein kinase activity PMID:18680479, PMID:19120698
PR:P33981
hTTK
acts_upstream_of_or_within GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
acts_upstream_of_or_within GO:0051310 metaphase plate congression PMID:20624902, PMID:22732840
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:20624902
acts_upstream_of_or_within GO:0032092 positive regulation of protein binding PMID:20624902
acts_upstream_of_or_within GO:0032092 positive regulation of protein binding PMID:22660415
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:22732840
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within NOT GO:0034501 protein localization to kinetochore PMID:20624902
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
enables GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-590746
located_in GO:0000776 kinetochore PMID:20624902
PR:000049845
hTTK/p(Act-loop_P+1-loop)
enables GO:0004672 protein kinase activity PMID:19120698
PR:P54199
yTTK
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:22521787
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:22521787
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:8688079
enables GO:0004672 protein kinase activity PMID:22521787, PMID:8688079
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P33981 hTTK

PMID:20624902

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