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Protein Ontology Report - VEGFA

PR:000017284 - http://purl.obolibrary.org/obo/PR_000017284
Ontology Information
PRO ID PR:000017284 Show OBO stanza / PAF
PRO name vascular endothelial growth factor A
Synonyms
PRO-short-label: EXACT: VEGFA
Gene-based: RELATED: VEGF
Other: EXACT: VEGF-A | VPF | vascular permeability factor
Definition A protein that is a translation product of the human VEGFA gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 3 organism-sequence 29
modification 1 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q00731-4
mVEGFA/iso:4
acts_upstream_of_or_within GO:0001938 positive regulation of endothelial cell proliferation MGI:1195544, PMID:9446618
enables GO:0008083 growth factor activity MGI:1195544, PMID:9446618
located_in GO:0005576 extracellular region MGI:1195544, PMID:9446618
PR:Q00731-2
mVEGFA/iso:2
acts_upstream_of_or_within GO:0048754 branching morphogenesis of an epithelial tube MGI:3613102, PMID:16375885
acts_upstream_of_or_within GO:0002053 positive regulation of mesenchymal cell proliferation MGI:3613102, PMID:16375885
acts_upstream_of_or_within GO:0030324 lung development MGI:3613102, PMID:16375885
acts_upstream_of_or_within GO:0001569 branching involved in blood vessel morphogenesis MGI:3710026, PMID:17428830
acts_upstream_of_or_within GO:0001525 angiogenesis MGI:3758404, PMID:17626017
acts_upstream_of_or_within GO:0048010 vascular endothelial growth factor receptor signaling pathway MGI:74931, PMID:1592003
acts_upstream_of_or_within GO:0060426 lung vasculature development MGI:1927039, PMID:11066091
acts_upstream_of_or_within GO:0001938 positive regulation of endothelial cell proliferation MGI:74931, PMID:1592003
enables GO:0043183 vascular endothelial growth factor receptor 1 binding MGI:3758404, PMID:17626017
enables GO:0005515 protein binding with PR:P97333 mNRP1 MGI:1860784, PMID:10705382
enables GO:0008201 heparin binding MGI:3758404, PMID:17626017
enables GO:0043184 vascular endothelial growth factor receptor 2 binding with PR:P35918 mKDR MGI:1860784, PMID:10705382
enables GO:0043184 vascular endothelial growth factor receptor 2 binding MGI:3758404, PMID:17626017
enables GO:0008201 heparin binding MGI:77585, PMID:8614412
enables GO:0005102 signaling receptor binding MGI:3758404, PMID:17626017
enables GO:0050840 extracellular matrix binding MGI:3758404, PMID:17626017
located_in GO:0005576 extracellular region MGI:77585, PMID:8614412
PR:Q00731-3
mVEGFA/iso:3
acts_upstream_of_or_within GO:0001938 positive regulation of endothelial cell proliferation MGI:74931, PMID:1592003
acts_upstream_of_or_within GO:0048010 vascular endothelial growth factor receptor signaling pathway MGI:74931, PMID:1592003
acts_upstream_of_or_within GO:0001525 angiogenesis MGI:3758404, PMID:17626017
located_in GO:0005615 extracellular space MGI:74931, PMID:1592003
located_in GO:0005576 extracellular region MGI:77585, PMID:8614412
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005576 extracellular region PR:Q00731-2 mVEGFA/iso:2

MGI:77585, PMID:8614412
PR:Q00731-3 mVEGFA/iso:3

MGI:77585, PMID:8614412
PR:Q00731-4 mVEGFA/iso:4

MGI:1195544, PMID:9446618
GO:0005615 extracellular space PR:Q00731-3 mVEGFA/iso:3

MGI:74931, PMID:1592003

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