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Protein Ontology Report - LPSR:2

PR:000025496 -
Ontology Information
PRO ID PR:000025496 Show OBO stanza
PRO name lipopolysaccharide receptor complex 2
PRO-short-label: EXACT: LPSR:2
Other: EXACT: TLR4MD2LPSCD14s complex
Definition A lipopolysaccharide receptor complex that contains the soluble form of CD14, and the lipopolysaccharide (LPS) bound to it. [PMID:1281215, PMID:16176659, PMID:7681988]
Comment Note: The soluble form of CD14 is able to transfer the lipopolysaccharide to MD-2 in the tissues where the membrane form is absent.
PRO Category complex
Parent GO:0046696 lipopolysaccharide receptor complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025496 PR:000003299 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 LY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form that has been N-glycosylated at positions equivalent to Asn-26 and Asn-114 of the amino acid sequence represented by UniProtKB:Q9Y6Y9-1. Example: UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:17569869, PRO:CNA, PRO:DAN, TLR:AMM]
PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 TLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
PR:000002147 CD14 molecule isoform 1 cleaved 2 soluble form CD14/iso:1/Clv:2/soluble A CD14 molecule isoform 1 cleaved 2 that lacks the GPI-anchor. [PMID:2779588]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]