Protein Ontology Report - hSIAH1/iso:1/Phos:1 PR:000025641 - http://purl.obolibrary.org/obo/PR_000025641

Ontology Information
PRO ID	PR:000025641 Show OBO stanza / PAF / GPI
PRO name	E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
Synonyms	PRO-short-label: EXACT: hSIAH1/iso:1/Phos:1 PRO-proteoform-std: EXACT: UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048
Definition	An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048. [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]
PRO Category	organism-modification
Parent	PR:000025627 E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000025641 hSIAH1/iso:1/Phos:1 Tyr-100/Tyr-126, MOD:00048 acts_upstream_of_or_within GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351 acts_upstream_of_or_within GO:0043525 positive regulation of neuron apoptotic process PMID:16230351 enables GO:0005515 protein binding increased relative to PR:000045369 hSIAH1/iso:1/UnPhos:1 with PR:Q69ZI1-1 mSH3RF1/iso:1 PMID:16230351

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