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Protein Ontology Report - MYD88:TIRAP:activated TLR4 receptor

PR:000025784 - http://purl.obolibrary.org/obo/PR_000025784
Ontology Information
PRO ID PR:000025784 Show OBO stanza / PAF
PRO name MYD88:TIRAP:activated TLR4 receptor
Synonyms
Other: EXACT: MYD88:Mal:activated TLR4 receptor | MyD88:Mal complexed with the activated TLR4 receptor
Definition A MYD88:TIRAP:activated TLR complex whose activated TLR component is TLR4 receptor. [PMID:16751103, PRO:CNA, PRO:DAN, TLR:AMM]
Comment Requested by=TLR.
PRO Category complex
Parent PR:000025774 MYD88:TIRAP:activated TLR complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025784 PR:000001740 myeloid differentiation primary response protein MyD88 MYD88 A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. [PMID:9575168, PRO:CNA] 2
PR:000003296 lymphocyte antigen 96 LY96 A protein that is a translation product of the human LY96 gene or a 1:1 ortholog thereof. [TLR:AMM] 2
PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein TIRAP A protein that is a translation product of the human TIRAP gene or a 1:1 ortholog thereof. [PRO:CNA] 2
PR:000001155 Toll-like receptor 4 TLR4 A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof. [PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000037475 PR:A5HNF6 myeloid differentiation primary response protein MyD88 (chicken) chick-MYD88 A myeloid differentiation primary response protein MyD88 that is encoded in the genome of chicken. [OMA:A5HNF6, PMID:18582498, PRO:CNA] 2
PR:A0A1D5NZX9 lymphocyte antigen 96 (chicken) chick-LY96 A lymphocyte antigen 96 that is encoded in the genome of chicken. [OMA:A0A1D5NZX9, TLR:AMM] 2
PR:Q7ZTG5 Toll-like receptor 4 (chicken) chick-TLR4 A Toll-like receptor 4 that is encoded in the genome of chicken. [PMID:18768894, PMID:20483729, PRO:CNA] 2
PR:Q4U127 Toll-interleukin 1 receptor domain-containing adaptor protein (chicken) chick-TIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of chicken. [OMA:Q4U127, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000027175 PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse) mMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA] 2
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA] 2
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000027174 PR:P22366-2 myeloid differentiation primary response protein MyD88 isoform 2 (mouse) mMYD88/iso:2 A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA] 2
PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA] 2
PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037475
MYD88:TIRAP:activated TLR4 receptor (chicken)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_25089
acts_upstream_of_or_within GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25089
located_in GO:0005886 plasma membrane Reactome:REACT_26615
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
acts_upstream_of_or_within GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_26615

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