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Protein Ontology Report - hSMAD2/iso:Long/Phos:2

PR:000025935 -
Ontology Information
PRO ID PR:000025935 Show OBO stanza / PAF / GPI
PRO name smad2 isoform Long phosphorylated 2 (human)
PRO-short-label: EXACT: hSMAD2/iso:Long/Phos:2
PRO-proteoform-std: NARROW: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
Definition A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047, Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046. [PMID:12193595]
Comment Kinase=("MAPK3"; PR:000026189; Thr-8/Thr-220/Ser-245/Ser-250/Ser-255). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
PRO Category organism-modification
Parent PR:000000651 smad2 isoform Long phosphorylated 2
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Long/Phos:2 forms found in complexes
hSMAD2/iso:Long/Phos:2 Component Complexes
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)

Functional Annotation
PRO Term GO Annotation Evidence
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within GO:0006355 regulation of DNA-templated transcription PMID:12193595
acts_upstream_of_or_within GO:0007165 signal transduction PMID:12193595
acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:12193595
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
enables GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:12193595
enables GO:0003712 transcription coregulator activity PMID:12193595
located_in GO:0005634 nucleus PMID:12193595, PMID:17074053
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025935 hSMAD2/iso:Long/Phos:2
Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
PMID:12193595, PMID:17074053