PRO Entry Report - PR:000025935

Protein Ontology Report - hSMAD2/iso:Long/Phos:2

PR:000025935 - http://purl.obolibrary.org/obo/PR_000025935

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000025935 Show OBO stanza / PAF

PRO name

smad2 isoform Long phosphorylated 2 (human)

Synonyms

PRO-short-label:	EXACT:	hSMAD2/iso:Long/Phos:2
PRO-proteoform-std:	NARROW:	UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046

Definition

A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047, Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046. [PMID:12193595]

Comment

Kinase=("MAPK3"; PR:000026189; Thr-8/Thr-220/Ser-245/Ser-250/Ser-255). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).

PRO Category

organism-modification

Parent

PR:000000651 smad2 isoform Long phosphorylated 2

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

hSMAD2/iso:Long/Phos:2 forms found in complexes

hSMAD2/iso:Long/Phos:2 Component	Complexes
PR:000025935 hSMAD2/iso:Long/Phos:2	PR:000025946 smad2-smad4 protein complex 3 (human)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	capable_of	GO:0003712 transcription coregulator activity	PMID:12193595
	capable_of	GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:12193595
	capable_of	GO:0046332 SMAD binding with PR:Q13485 hSMAD4	PMID:12193595
	located_in	GO:0005634 nucleus	PMID:12193595, PMID:17074053
	participates_in	GO:0007165 signal transduction	PMID:12193595
	participates_in	GO:0007183 SMAD protein complex assembly	PMID:12193595
	participates_in	GO:0006355 regulation of transcription, DNA-templated	PMID:12193595

Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0046332 SMAD binding	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046 with PR:Q13485 hSMAD4	PMID:12193595
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595
GO:0003712 transcription coregulator activity	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0007183 SMAD protein complex assembly	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595
GO:0006355 regulation of transcription, DNA-templated	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595
GO:0007165 signal transduction	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:000025935 hSMAD2/iso:Long/Phos:2 Thr-8/Thr-220, MOD:00047\|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046	PMID:12193595, PMID:17074053

top