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Protein Ontology Report - hSMAD2/iso:Long/Phos:3

PR:000025936 -
Ontology Information
PRO ID PR:000025936 Show OBO stanza / PAF / GPI
PRO name smad2 isoform Long phosphorylated 3 (human)
PRO-short-label: EXACT: hSMAD2/iso:Long/Phos:3
PRO-proteoform-std: EXACT: UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046
Definition A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046. [PMID:11027280]
Comment Kinase=("CAMK-II"; PR:000003197; Ser-240). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
PRO Category organism-modification
Parent PR:000000652 smad2 isoform Long phosphorylated 3
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Long/Phos:3 forms found in complexes
hSMAD2/iso:Long/Phos:3 Component Complexes
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)

Functional Annotation
PRO Term GO Annotation Evidence
Ser-240/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within GO:0007165 signal transduction PMID:11027280
acts_upstream_of_or_within GO:0007183 SMAD protein complex assembly PMID:11027280
enables GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:11027280
enables NOT GO:0003713 transcription coactivator activity PMID:11027280
located_in GO:0005737 cytoplasm PMID:11027280
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000025936 hSMAD2/iso:Long/Phos:3
Ser-240/Ser-465/Ser-467, MOD:00046