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Protein Ontology Report - hSMAD2/iso:Short/Phos:1

PR:000025938 - http://purl.obolibrary.org/obo/PR_000025938
Ontology Information
PRO ID PR:000025938 Show OBO stanza / PAF
PRO name smad2 isoform Short phosphorylated 1 (human)
Synonyms
PRO-short-label: EXACT: hSMAD2/iso:Short/Phos:1
PRO-proteoform-std: EXACT: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046
Definition A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046. [PRO:CNA]
Comment Kinase=("TGFBR1"; PR:000025963; Ser-435/Ser-437).
PRO Category organism-modification
Parent PR:000000656 smad2 isoform Short phosphorylated 1
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Short/Phos:1 forms found in complexes
hSMAD2/iso:Short/Phos:1 Component Complexes
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000025938
hSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
capable_of GO:0003700 DNA-binding transcription factor activity PMID:9873005
capable_of GO:0003712 transcription coregulator activity PMID:14701940, PMID:9873005
capable_of GO:0003677 DNA binding PMID:14701940, PMID:9873005
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025938 hSMAD2/iso:Short/Phos:1
Ser-435/Ser-437, MOD:00046
PMID:9873005

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