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Protein Ontology Report - h(SMAD2:SMAD4):3

PR:000025946 -
Ontology Information
PRO ID PR:000025946 Show OBO stanza / PAF / GPI
PRO name smad2-smad4 protein complex 3 (human)
PRO-short-label: EXACT: h(SMAD2:SMAD4):3
Definition A smad2-smad4 protein complex 3 whose components are encoded in the genome of human. [PMID:12193595]
PRO Category organism-complex
Parent PR:000025969 smad2-smad4 protein complex 3
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025946 PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2 A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046. [PMID:12193595]

Functional Annotation
PRO Term GO Annotation Evidence
smad2-smad4 protein complex 3 (human)
acts_upstream_of_or_within GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595
located_in GO:0005634 nucleus PMID:12193595
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025946 smad2-smad4 protein complex 3 (human)