| PRO ID |
PR:000026222
Show OBO stanza
/ GPI
|
| PRO name |
neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human) |
| Synonyms |
| PRO-short-label: |
EXACT: |
hL1CAM/iso:1/SigPep-/Phos:1 |
| PRO-proteoform-std: |
EXACT: |
UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048 |
| PRO-proteoform-ftid: |
EXACT: |
PRO_0000015022, Tyr-1176, MOD:00048 |
|
| Definition |
A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. Tyr-1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048.
[PMID:12082080, PRO:CNA]
|
| PRO Category |
organism-modification |
| Parent |
PR:000026192 neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 |
| Taxon |
NCBITaxon:9606 Homo sapiens |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
|
