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Protein Ontology Report - hL1CAM/iso:1/SigPep-/Phos:1

PR:000026222 - http://purl.obolibrary.org/obo/PR_000026222
Ontology Information
PRO ID PR:000026222 Show OBO stanza
PRO name neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)
Synonyms
PRO-short-label: EXACT: hL1CAM/iso:1/SigPep-/Phos:1
PRO-proteoform-std: EXACT: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048
PRO-proteoform-ftid: EXACT: PRO_0000015022, Tyr-1176, MOD:00048
Definition A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. Tyr-1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048. [PMID:12082080, PRO:CNA]
PRO Category organism-modification
Parent PR:000026192 neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape


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Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

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