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Protein Ontology Report - PML

PR:000026474 - http://purl.obolibrary.org/obo/PR_000026474
Ontology Information
PRO ID PR:000026474 Show OBO stanza / PAF
PRO name transcription factor PML
Synonyms
PRO-short-label: EXACT: PML
Gene-based: RELATED: MYL | PP8675 | RNF71 | TRIM19
Other: EXACT: RING finger protein 71 | Tripartite motif-containing protein 19
Definition A tripartite motif-containing protein that is a translation product of the human PML gene or a 1:1 ortholog thereof. [PMID:20832753, PRO:CNA, PRO:DAN]
PRO Category gene
Parent PR:000044733 tripartite motif-containing protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 5 organism-sequence 15
modification 1 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P29590-3
hPML/iso:3
acts_upstream_of_or_within GO:0006915 apoptotic process PMID:9583681
acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:9583681
acts_upstream_of_or_within GO:0045930 negative regulation of mitotic cell cycle PMID:9395203
acts_upstream_of_or_within GO:0030578 PML body organization PMID:10779416
acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9395203
acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9583681
acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:7935403
enables GO:0046982 protein heterodimerization activity PMID:7935403
enables GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006
enables GO:0005515 protein binding with PR:Q64127 mTRIM24 PMID:10610177
enables GO:0005515 protein binding with PR:P45481 mCREBBP PMID:10610177
enables GO:0005515 protein binding with PR:P04489 E4orf3 (ADE05) PMID:16501113
located_in GO:0031965 nuclear membrane PMID:16778193
located_in GO:0005634 nucleus PMID:9294197
located_in GO:0005737 cytoplasm PMID:16778193
PR:P29590-2
hPML/iso:2
acts_upstream_of_or_within GO:0002230 positive regulation of defense response to virus by host PMID:16873256
located_in GO:0005634 nucleus PMID:16778193
located_in GO:0005737 cytoplasm PMID:16778193
PR:P29590-1
hPML/iso:1
enables GO:0005515 protein binding with PR:Q13164 hMAPK7 PMID:20832753
located_in GO:0005634 nucleus PMID:16778193
located_in GO:0005737 cytoplasm PMID:9885291
located_in GO:0005737 cytoplasm PMID:16778193
PR:P29590-5
hPML/iso:5
acts_upstream_of_or_within GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage PMID:12402044
acts_upstream_of_or_within GO:0032938 negative regulation of translation in response to oxidative stress PMID:16915281
acts_upstream_of_or_within GO:0045892 negative regulation of DNA-templated transcription PMID:9448006
acts_upstream_of_or_within GO:0006605 protein targeting PMID:15195100
acts_upstream_of_or_within GO:0006605 protein targeting PMID:11080164
acts_upstream_of_or_within GO:0006915 apoptotic process PMID:11080164
acts_upstream_of_or_within GO:0050821 protein stabilization PMID:12773567
acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:12773567
acts_upstream_of_or_within GO:0030308 negative regulation of cell growth PMID:9448006
acts_upstream_of_or_within GO:0031065 positive regulation of histone deacetylation PMID:11259576
enables GO:0005515 protein binding with PR:Q92547 hTOPBP1 PMID:12773567
enables GO:0005515 protein binding with PR:Q13547 hHDAC1 PMID:11259576
enables GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197
enables GO:0005515 protein binding with PR:P62913 hRPL11 PMID:15195100
enables GO:0005515 protein binding with PR:O96017 hCHEK2 PMID:12402044
enables GO:0005515 protein binding with PR:P04637 hTP53 PMID:11080164
enables GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590
enables GO:0005515 protein binding with PR:Q92769 hHDAC2 PMID:11259576
enables GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197
enables GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006
enables GO:0003713 transcription coactivator activity PMID:15626733
enables GO:0003713 transcription coactivator activity PMID:11080164
enables GO:0005515 protein binding with PR:O15379 hHDAC3 PMID:11259576
enables GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590
located_in GO:0016363 nuclear matrix PMID:11080164
located_in GO:0005730 nucleolus PMID:16778193
located_in GO:0005737 cytoplasm PMID:16778193
located_in GO:0016605 PML body PMID:9448006
PR:P29590-4
hPML/iso:4
acts_upstream_of_or_within GO:0002230 positive regulation of defense response to virus by host PMID:16873257
acts_upstream_of_or_within GO:0030578 PML body organization PMID:8643677
enables GO:0005515 protein binding with PR:P14373 hTRIM27 PMID:9570750
enables GO:0005515 protein binding with PR:Q03014 hHHEX PMID:10597310
enables GO:0005515 protein binding with PR:P63165 hSUMO1 PMID:9885291
enables GO:0005515 protein binding with PR:P63073 mEIF4E PMID:11500381
enables GO:0008270 zinc ion binding PMID:7729428
enables GO:0005515 protein binding with PR:Q9UER7-1 hDAXX/iso:1 PMID:10669754
enables GO:0005515 protein binding with PR:P63279 hUBE2I PMID:9885291
enables GO:0005515 protein binding with PR:P23769 hGATA2 PMID:10938104
enables GO:0050897 cobalt ion binding PMID:7729428
located_in GO:0016605 PML body PMID:9885291
PR:000026480
hPML/iso:1/Phos:1
Ser-403, MOD:00046|Thr-409, MOD:00047
located_in GO:0005634 nucleus PMID:20832753
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016363 nuclear matrix PR:P29590-5 hPML/iso:5

PMID:11080164
GO:0016605 PML body PR:P29590-4 hPML/iso:4

PMID:9885291
PR:P29590-5 hPML/iso:5

PMID:9448006
GO:0005737 cytoplasm PR:P29590-1 hPML/iso:1

PMID:9885291
PR:P29590-1 hPML/iso:1

PMID:16778193
PR:P29590-2 hPML/iso:2

PMID:16778193
PR:P29590-3 hPML/iso:3

PMID:16778193
PR:P29590-5 hPML/iso:5

PMID:16778193
GO:0005730 nucleolus PR:P29590-5 hPML/iso:5

PMID:16778193
GO:0031965 nuclear membrane PR:P29590-3 hPML/iso:3

PMID:16778193
GO:0005634 nucleus PR:000026480 hPML/iso:1/Phos:1
Ser-403, MOD:00046|Thr-409, MOD:00047
PMID:20832753
PR:P29590-1 hPML/iso:1

PMID:16778193
PR:P29590-2 hPML/iso:2

PMID:16778193
PR:P29590-3 hPML/iso:3

PMID:9294197

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