PRO Entry Report - PR:000028994

Protein Ontology Report - hAKT1/iso:1/Phos:1

PR:000028994 - http://purl.obolibrary.org/obo/PR_000028994

Protein Forms Annotations

Ontology Information

PRO ID

PR:000028994 Show OBO stanza / PAF

PRO name

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)

Synonyms

PRO-short-label:	EXACT:	hAKT1/iso:1/Phos:1
PRO-proteoform-std:	EXACT:	UniProtKB:P31749-1, Thr-308, MOD:00047\|Ser-473, MOD:00046
Other:	RELATED:	Akt1 active form (human)

Definition

A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047, Ser-473, MOD:00046. [PMID:8978681, PRO:ALI]

Comment

Kinase=("MAPKAPK2"; PR:000010165).

PRO Category

organism-modification

Parent

PR:000003103 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046	capable_of	GO:0005515 protein binding with PR:O14746-1 hTERT/iso:1	PMID:12586360
	capable_of	GO:0004672 protein kinase activity	PMID:8978681
	capable_of	GO:0005515 protein binding with PR:P41279-1 hMAP3K8/iso:1	PMID:12138205
	capable_of	GO:0004674 protein serine/threonine kinase activity	PMID:12138205
	participates_in	GO:0051092 positive regulation of NF-kappaB transcription factor activity	PMID:12138205
	participates_in	GO:0032869 cellular response to insulin stimulus	PMID:8978681

Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0004674 protein serine/threonine kinase activity	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046	PMID:12138205
GO:0004672 protein kinase activity	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046	PMID:8978681
GO:0005515 protein binding	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046 with PR:O14746-1 hTERT/iso:1	PMID:12586360
GO:0005515 protein binding	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046 with PR:P41279-1 hMAP3K8/iso:1	PMID:12138205

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0051092 positive regulation of NF-kappaB transcription factor activity	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046	PMID:12138205
GO:0032869 cellular response to insulin stimulus	PR:000028994 hAKT1/iso:1/Phos:1 Thr-308, MOD:00047\|Ser-473, MOD:00046	PMID:8978681

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